Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells - Centre de recherche Bichat-Beaujon Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2018

Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells

Résumé

Cross-presentation allows exogenous antigen presentation in association with major histocompatibility complex class I molecules, a process crucial for the priming of CD8+ T-cell responses against viruses and tumors. By contrast to conventional dendritic cells (cDC), which cross-present antigens in the steady state, plasmacytoid dendritic cells (pDC) acquire this ability only after stimulation by Toll-like receptor (TLR) ligands. The intracellular pathways accounting for this functional difference are still unknown. Here we show that the induction of cross-presentation by pDCs is regulated by mitochondria through a reactive oxygen species (ROS)-dependent mechanism, involving pH alkalization and antigen protection. The reduction of mitochondrial ROS production dramatically decreases the cross-presentation capacity of pDCs, leading to a strong reduction of their capacity to trigger CD8+ T-cell responses. Our results demonstrate the importance of mitochondrial metabolism in pDC biology, particularly for the induction of adaptive immune responses.
Fichier principal
Vignette du fichier
s41467-018-04686-8.pdf (1.23 Mo) Télécharger le fichier
Loading...

Dates et versions

pasteur-01899394 , version 1 (19-10-2018)

Licence

Paternité

Identifiants

Citer

Marine Oberkampf, Camille Guillerey, Juliette Mouriès, Pierre Rosenbaum, Catherine Fayolle, et al.. Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nature Communications, 2018, 9 (1), pp.2241. ⟨10.1038/s41467-018-04686-8⟩. ⟨pasteur-01899394⟩
132 Consultations
174 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More