Altered Sexual Maturation and Gamete Production in Wild Roach (Rutilus rutilus) Living in Rivers That Receive Treated Sewage Effluents1, Biology of Reproduction, vol.15, issue.2, pp.272-281, 2002. ,
DOI : 10.1016/0141-1136(85)90038-8
Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish, Environmental Health Perspectives, vol.112, issue.17, pp.1725-1733, 2004. ,
DOI : 10.1289/ehp.7209
URL : https://hal.archives-ouvertes.fr/ineris-00961892
Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos, A. Ten years of mixing cocktails: A review of combination effects of endocrine-disrupting chemicals, Environ. Health Perspect, pp.115-98, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00877371
Effects of binary mixtures of xenoestrogens on gonadal development and reproduction in zebrafish, Aquatic Toxicology, vol.80, issue.4, pp.382-395, 2006. ,
DOI : 10.1016/j.aquatox.2006.10.004
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals, Aquatic Toxicology, vol.138, issue.139, pp.138-139 ,
DOI : 10.1016/j.aquatox.2013.05.001
URL : https://hal.archives-ouvertes.fr/hal-00877351
Assessing combined toxicity of estrogen receptor agonists in a primary culture of rainbow trout (Oncorhynchus mykiss) hepatocytes, Aquatic Toxicology, vol.101, issue.1, pp.186-195, 2011. ,
DOI : 10.1016/j.aquatox.2010.09.018
-Octylphenol Detected in the E-SCREEN Assay, Environmental Science & Technology, vol.38, issue.23, pp.6343-6352, 2004. ,
DOI : 10.1021/es049681e
), Environmental Science & Technology, vol.35, issue.12, pp.2476-2481, 2001. ,
DOI : 10.1021/es001767u
Effects of estradiol and ethinylestradiol on sperm quality, fertilization, and embryo???larval survival of pejerrey fish (Odontesthes bonariensis), Aquatic Toxicology, vol.167, pp.191-199, 2015. ,
DOI : 10.1016/j.aquatox.2015.08.011
Effects of individual and binary mixtures of estrogens on male goldfish (Carassius auratus), Fish Physiology and Biochemistry, vol.137, issue.467, pp.1927-1935, 2014. ,
DOI : 10.1016/j.chemosphere.2006.02.019
Additive effects of levonorgestrel and ethinylestradiol on brain aromatase ( cyp19a1b ) in zebrafish specific in vitro and in vivo bioassays, Toxicology and Applied Pharmacology, vol.307, pp.108-114, 2016. ,
DOI : 10.1016/j.taap.2016.07.023
URL : https://hal.archives-ouvertes.fr/hal-01367151
Effects of estradiol in adult neurogenesis and brain repair in zebrafish, Horm. Behav, vol.2013, issue.63, pp.193-207 ,
URL : https://hal.archives-ouvertes.fr/inserm-00831715
Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish, The Journal of Comparative Neurology, vol.1334, issue.1, pp.150-167, 2007. ,
DOI : 10.1016/S0304-4165(96)00115-8
URL : https://hal.archives-ouvertes.fr/hal-00096389
-acting element involved in cell-specific expression of the zebrafish brain aromatase gene, Molecular Reproduction and Development, vol.54, issue.10, pp.1549-1557, 2008. ,
DOI : 10.1128/MCB.6.8.2784
Assessment of Xenoestrogens Using Three Distinct Estrogen Receptors and the Zebrafish Brain Aromatase Gene in a Highly Responsive Glial Cell System, Environmental Health Perspectives, vol.114, issue.5, pp.752-758, 2006. ,
DOI : 10.1289/ehp.8141
URL : https://hal.archives-ouvertes.fr/hal-00068400
Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?, International Journal of Molecular Sciences, vol.24, issue.7, p.1381, 2017. ,
DOI : 10.1038/cdd.2010.20
URL : https://hal.archives-ouvertes.fr/hal-01560283
SIGNIFICANCE TESTING OF SYNERGISTIC/ANTAGONISTIC, DOSE LEVEL???DEPENDENT, OR DOSE RATIO???DEPENDENT EFFECTS IN MIXTURE DOSE???RESPONSE ANALYSIS, Environmental Toxicology and Chemistry, vol.24, issue.10, pp.2701-2713, 2005. ,
DOI : 10.1897/04-431R.1
The problem of synergism and antagonism of combined drugs, Arzneimittelforschung, vol.3, pp.285-290, 1953. ,
Comparison of in Vivo and in Vitro Reporter Gene Assays for Short-Term Screening of Estrogenic Activity, Environmental Science & Technology, vol.36, issue.20, pp.4410-4415, 2002. ,
DOI : 10.1021/es010323a
Selective Activation of Zebrafish Estrogen Receptor Subtypes by Chemicals by Using Stable Reporter Gene Assay Developed in a Zebrafish Liver Cell Line, Toxicological Sciences, vol.81, issue.2, pp.439-449, 2012. ,
DOI : 10.1093/toxsci/kfh180
URL : https://hal.archives-ouvertes.fr/hal-00750158
Phytoestrogens and mycoestrogens in surface waters ??? Their sources, occurrence, and potential contribution to estrogenic activity, Environment International, vol.81, pp.26-44, 2015. ,
DOI : 10.1016/j.envint.2015.03.019
Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta, Biochemical Pharmacology, vol.71, issue.10, pp.1459-1469, 2006. ,
DOI : 10.1016/j.bcp.2006.02.002
In vivo bioluminescence imaging to evaluate estrogenic activities of endocrine disrupters, Analytical Biochemistry, vol.340, issue.2, pp.295-302, 2005. ,
DOI : 10.1016/j.ab.2005.02.032
A stable fish reporter cell line to study estrogen receptor transactivation by environmental (xeno)estrogens, Toxicology in Vitro, vol.23, issue.8, pp.1450-1454, 2009. ,
DOI : 10.1016/j.tiv.2009.07.003
URL : https://hal.archives-ouvertes.fr/hal-00453656
Studying the effects of genistein on gene expression of fish embryos as an alternative testing approach for endocrine disruption, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.157, issue.1, pp.41-53, 2013. ,
DOI : 10.1016/j.cbpc.2012.09.005
Developing a marker of exposure to xenoestrogen mixtures in human serum, Environmental Health Perspectives, vol.105, issue.Suppl 3, pp.647-654, 1997. ,
DOI : 10.1289/ehp.97105s3647
Response of MCF-7 human breast cancer cells to some binary mixtures of oestrogenic compounds in-vitro, Journal of Pharmacy and Pharmacology, vol.31, issue.Suppl., pp.1549-1554, 2001. ,
DOI : 10.1021/es960530o
Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) ??? An analysis with nonlinear isobolograms, Toxicology and Applied Pharmacology, vol.234, issue.1, pp.77-88, 2009. ,
DOI : 10.1016/j.taap.2008.09.032
Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells, Food and Chemical Toxicology, vol.45, issue.11, pp.2319-2330, 2007. ,
DOI : 10.1016/j.fct.2007.06.011
Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity), Toxicology Letters, vol.181, issue.2 ,
DOI : 10.1016/j.toxlet.2008.07.006
Assessment of Interactions of Diverse Ternary Mixtures in an Estrogen Receptor-?? Reporter Assay, Toxicology and Applied Pharmacology, vol.180, issue.1, pp.11-21, 2002. ,
DOI : 10.1006/taap.2001.9346
Differential Effects of Xenoestrogens on Coactivator Recruitment by Estrogen Receptor (ER) ?? and ER??, Journal of Biological Chemistry, vol.44, issue.7, pp.35986-35993, 2000. ,
DOI : 10.1006/taap.1997.8169
Estrogen Receptors ?? and ?? as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding, Molecular Endocrinology, vol.22, issue.5, pp.1032-1043, 2008. ,
DOI : 10.1210/me.2007-0356
(aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells, genesis, vol.1, issue.2, pp.67-73, 2009. ,
DOI : 10.1007/978-3-0348-8979-7
URL : https://hal.archives-ouvertes.fr/hal-00364893
Molecular Characterization of Three Estrogen Receptor Forms in Zebrafish: Binding Characteristics, Transactivation Properties, and Tissue Distributions1, Biology of Reproduction, vol.98, issue.6, pp.1881-1892, 2002. ,
DOI : 10.1073/pnas.041617498
Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene, The Journal of Comparative Neurology, vol.102, issue.4, pp.304-320, 2005. ,
DOI : 10.1007/978-3-0348-8979-7_1
URL : https://hal.archives-ouvertes.fr/hal-00294769
R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing, 2014. ,
Bioassays analysis using R, J. Stat. Softw, vol.12, pp.1-22, 2005. ,
The expected effect of a combination of agents: the general solution, Journal of Theoretical Biology, vol.114, issue.3, pp.413-431, 1985. ,
DOI : 10.1016/S0022-5193(85)80176-4
A Unifying Concept for Assessing Toxicological Interactions: Changes in Slope, Toxicological Sciences, vol.88, issue.2, pp.287-297, 2005. ,
DOI : 10.1006/rtph.2002.1570
Toxicity of a Mixture of Dissimilarly Acting Substances to Natural Algal Communities:?? Predictive Power and Limitations of Independent Action and Concentration Addition, Environmental Science & Technology, vol.38, issue.23, pp.6363-6370, 2004. ,
DOI : 10.1021/es0497678
Mixtures of endocrine disruptors: How similar must mechanisms be for concentration addition to apply? Toxicology 2013, pp.129-133 ,
Predicting the joint algal toxicity of multi-component s-triazine mixtures at low-effect concentrations of individual toxicants, Aquat. Toxicol, vol.56, pp.13-32, 2001. ,
A mathematical approach to study combined effects of toxicants in vitro: Evaluation of the Bliss independence criterion and the Loewe additivity model, Toxicology in Vitro, vol.21, issue.5, pp.759-769, 2007. ,
DOI : 10.1016/j.tiv.2007.03.003
Modeling mixtures of thyroid gland function disruptors in a vertebrate alternative model, the zebrafish eleutheroembryo, Toxicology and Applied Pharmacology, vol.269, issue.2, pp.169-175, 2013. ,
DOI : 10.1016/j.taap.2013.02.015
The search for synergy?A critical-review from a response-surface perspective, Pharmacol. Rev, vol.47, pp.331-385, 1995. ,
Isobolographic analysis of interactions: an update on applications and utility, Toxicology, vol.105, issue.2-3, pp.161-179, 1995. ,
DOI : 10.1016/0300-483X(95)03210-7
Synergisms with mixtures of xenoestrogens: A reevaluation using the method of isoboles, Science of The Total Environment, vol.221, issue.1, pp.59-73, 1998. ,
DOI : 10.1016/S0048-9697(98)00261-7
Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method, Cancer Research, vol.70, issue.2, pp.440-446, 2010. ,
DOI : 10.1158/0008-5472.CAN-09-1947
URL : http://cancerres.aacrjournals.org/content/canres/70/2/440.full.pdf
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors, Advances in Enzyme Regulation, vol.22, pp.27-55, 1984. ,
DOI : 10.1016/0065-2571(84)90007-4
Utilizing Concentration-Response Data from Individual Components to Detect Statistically Significant Departures from Additivity in Chemical Mixtures, Biometrics, vol.51, issue.4, pp.1264-1277, 1995. ,
DOI : 10.2307/2533258
Quantifying synergism/antagonism using nonlinear mixed-effects modeling: A simulation study, Statistics in Medicine, vol.37, issue.7, pp.1040-1061, 2008. ,
DOI : 10.1139/y90-103
An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments, Environmental and Ecological Statistics, vol.46, issue.4, pp.383-397, 2007. ,
DOI : 10.1139/f65-042
Dfoptim: Derivative-Free Optimization, 2011. ,