L. A. Afonso and P. Duarte, Un nouveau test pour la distribution uniforme, Rev Statistiques Appliquée, vol.40, pp.77-79, 1992.

J. Ahlers, F. Stock, and B. Werschkun, Integrated testing and intelligent assessment???new challenges under REACH, Environmental Science and Pollution Research, vol.18, issue.11???12, pp.565-572, 2008.
DOI : 10.1007/s11356-008-0043-y

E. Benfenati, Predicting toxicity through computers: a changing world, Chemistry Central Journal, vol.1, issue.1, p.32, 2007.
DOI : 10.1186/1752-153X-1-32

H. C. Bowden, J. M. Tesh, and F. W. Ross, Effects of female sex hormones in whole embryo culture, Toxicology in Vitro, vol.7, issue.6, pp.799-802, 1993.
DOI : 10.1016/0887-2333(93)90083-H

C. F. Burman and S. Senn, Examples of option values in drug development, Pharmaceutical Statistics, vol.54, issue.2, pp.113-125, 2003.
DOI : 10.1002/pst.41

L. Cicurel and B. P. Schmid, Postimplantation embryo culture for the assessment of the teratogenic potential and potency of compounds, Experientia, vol.53, issue.10, pp.833-840, 1988.
DOI : 10.1007/BF01941180

M. E. Cosenza and J. Bidanset, Effects of chlorpyrifos on neuronal development in rat embryo midbrain micromass cultures, Vet. Hum. Toxicol, vol.37, issue.2, pp.118-121, 1995.

P. F. Cumberland, M. Richold, J. F. Parsons, and M. K. Pratten, Further evaluation of a teratogenicity screen using an intravitelline injection technique, Toxicology in Vitro, vol.8, issue.2, pp.153-166, 1994.
DOI : 10.1016/0887-2333(94)90178-3

S. J. Enoch, M. T. Cronin, J. C. Madden, and M. Hewitt, Formation of Structural Categories to Allow for Read-Across for Teratogenicity, QSAR & Combinatorial Science, vol.18, issue.6-7, 2009.
DOI : 10.1002/qsar.200960011

E. Genschow, H. Spielman, G. Scholz, I. Pohl, A. Seiler et al., Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests, ATLA, vol.32, pp.209-244, 2004.

A. Golbraikh and A. Tropsha, Beware of q2!, Journal of Molecular Graphics and Modelling, vol.20, issue.4, pp.269-276, 2002.
DOI : 10.1016/S1093-3263(01)00123-1

P. Gramatica, Principles of QSAR models validation: internal and external, QSAR & Combinatorial Science, vol.15, issue.5, pp.694-701, 2007.
DOI : 10.1002/qsar.200610151

P. Gramatica, Evaluation of different statistical approaches to the validation of Quantitative Structure -Activity Relationships Available online at: http://ecb.jrc.it, 2004.

C. Grindon, R. Combes, M. T. Cronin, D. Roberts, and J. F. Garrod, Integrated testing strategies for use in the EU REACH system, ATLA, vol.34, pp.407-427, 2006.

C. Grindon, R. Combes, M. T. Cronin, D. Roberts, and J. F. Garrod, Integrated decisiontree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation, ATLA, vol.36, pp.65-80, 2008.

D. K. Hansen and T. F. Grafton, Comparison of dexamethasone-induced embryotoxicity in vitro in mouse and rat embryos, Teratogenesis, Carcinogenesis, and Mutagenesis, vol.15, issue.6, pp.281-289, 1994.
DOI : 10.1002/tcm.1770140605

O. P. Flint and T. C. Orton, An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells, Toxicology and Applied Pharmacology, vol.76, issue.2, pp.383-395, 1984.
DOI : 10.1016/0041-008X(84)90020-6

S. O. Hansson and C. Ruden, Towards a theory of tiered testing, Regulatory Toxicology and Pharmacology, vol.48, issue.1, pp.35-44
DOI : 10.1016/j.yrtph.2006.12.003

R. Kavlock, D. Barr, K. Boekelheide, W. Breslin, P. Breysse et al., NTP-CERHR Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate, Reprod Toxicol, vol.22, pp.291-299, 2006.

A. Lione and A. R. Scialli, The developmental toxicity of indomethacin and sulindac, Reproductive Toxicology, vol.9, issue.1, 1995.
DOI : 10.1016/0890-6238(94)00051-W

E. Menegola, M. L. Broccia, D. Renzo, F. Giavini, and E. , Acetaldehyde in vitro exposure and apoptosis: a possible mechanism of teratogenesis, Alcohol, vol.23, issue.1, pp.35-39, 2001.
DOI : 10.1016/S0741-8329(00)00132-4

G. M. Morris and C. E. Steele, Comparison of the effects of retinol and retinoic acid on postimplantation rat embryos in vitro, Teratology, vol.159, issue.1, pp.109-120, 1976.
DOI : 10.1002/tera.1420150115

D. R. Newall and K. E. Beedles, The stem-cell test: an in vitro assay for teratogenic potential. Results of a blind trial with 25 compounds, Toxicology in Vitro, vol.10, issue.2, pp.229-240, 1996.
DOI : 10.1016/0887-2333(95)00110-7

A. R. Pery, A. Henegar, and E. Mombelli, Maximum-Likelihood Estimation of Predictive Uncertainty in Probabilistic QSAR Modeling, QSAR & Combinatorial Science, vol.48, issue.3, pp.338-344, 2009.
DOI : 10.1002/qsar.200860116
URL : https://hal.archives-ouvertes.fr/ineris-00963175

A. H. Piersma, E. Grenschow, A. Verhoef, M. Q. Spanjersberg, N. A. Brown et al., Validation of the post-implantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests, ATLA, vol.32, pp.275-307, 2004.

J. Renault, C. Meicion, and A. Cordier, Limb bud cell culture for in vitro teratogen screening: Validation of an improved assessment method using 51 compounds, Teratogenesis, Carcinogenesis, and Mutagenesis, vol.282, issue.2, 1989.
DOI : 10.1002/tcm.1770090204

H. E. Ritchie, W. S. Webster, C. Eckhoff, and D. J. Oakes, Model predicting the teratogenic potential of retinyl palmitate, using a combined in vivo/in vitro approach, Teratology, vol.68, issue.3-4, pp.113-123, 1998.
DOI : 10.1002/(SICI)1096-9926(199809/10)58:3/4<113::AID-TERA7>3.0.CO;2-O

G. Schuurmann, R. U. Ebert, J. Chen, B. Wang, and R. Kuhne, External Validation and Prediction Employing the Predictive Squared Correlation Coefficient ??? Test Set Activity Mean vs Training Set Activity Mean, Journal of Chemical Information and Modeling, vol.48, issue.11, pp.2140-2145, 2008.
DOI : 10.1021/ci800253u

H. Spielmann, I. Pohl, B. Döring, M. Liebsch, and F. Moldenhauer, The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells, In Vitro Toxicol, vol.10, issue.1, pp.119-127, 1997.
DOI : 10.1007/978-3-7091-7500-2_69

H. Huuskonen, F. Paillard, and A. Seiler, Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests, ATLA, vol.32, pp.245-274, 2004.

R. Todeschini and V. Consonni, Handbook of Molecular Descriptors, Methods and Principles in Medicinal Chemistry, vol.11, 2000.
DOI : 10.1002/9783527613106

A. Tropsha, P. Gramatica, and V. K. Gombar, The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models, QSAR & Combinatorial Science, vol.38, issue.1, pp.69-77, 2003.
DOI : 10.1002/qsar.200390007

Z. Nieden, N. I. Ruf, L. J. Kempka, G. Hildebrand, H. Ahr et al., Molecular markers in embryonic stem cells, Molecular markers in embryonic stem cells, pp.455-461, 2001.
DOI : 10.1016/S0887-2333(01)00071-6