PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

Abstract : Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive modelling of inter-individual variability in the absorption, distribution, metabolism and excretion of environmental chemicals. When needed, Markov chain Monte Carlo methods and multilevel population models can be jointly used for a Bayesian calibration of a PBPK model, to improve our understanding of the determinants of population heterogeneity and differential susceptibility. This article reviews those developments and illustrates them with recent applications to environmentally relevant questions.
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Frédéric Y. Bois, Massoud Jamei, Harvey J. Clewell. PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals. Toxicology, Elsevier, 2010, 278 (3), pp.256-267. ⟨10.1016/j.tox.2010.06.007⟩. ⟨ineris-00961755⟩

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