G. Ankley, K. Jensen, M. Kahl, E. Makynen, L. Blake et al., KETOCONAZOLE IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS): REPRODUCTIVE TOXICITY AND BIOLOGICAL COMPENSATION, Environmental Toxicology and Chemistry, vol.26, issue.6, pp.1214-1223, 2007.
DOI : 10.1897/06-428R.1

M. Ayub and M. Levell, Inhibition of Testicular 17-Alpha-Hydroxylase and 17,20-Lyase but Not 3- 449 Beta-Hydroxysteroid Dehydrogenase-Isomerase or 17-Beta-Hydroxysteroid Oxidoreductase 450 by Ketoconazole and Other Imidazole Drugs, J Steroid Biochem Mol Biol, vol.2887, issue.5, pp.521-5310022, 1987.

D. Baudiffier, N. Hinfray, M. Vosges, N. Creusot, E. Chadili et al., Brion F (2012) A 453 critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on 454 testicular steroidogenesis in adult zebrafish, Toxicology, vol.298, pp.1-330

N. Berenzen, A. Lentzen-godding, M. Probst, H. Schulz, R. Schulz et al., A comparison of predicted and measured levels of runoff-related pesticide concentrations in small lowland streams on a landscape level, Chemosphere, vol.58, issue.5, pp.683-691, 2005.
DOI : 10.1016/j.chemosphere.2004.05.009

A. Sharpe and C. Tyler, Are Toxicological Responses in Laboratory (Inbred) Zebrafish 460 Representative of Those in Outbred (Wild) Populations? -A Case Study with an Endocrine 461 Disrupting Chemical, Environ Sci Technol, vol.45, issue.9, pp.4166-417210, 2011.

K. Burns and M. Matzuk, Minireview: Genetic Models for the Study of Gonadotropin Actions, Endocrinology, vol.143, issue.8, pp.2823-2835, 2002.
DOI : 10.1210/endo.143.8.8928

S. Chen, J. Bogerd, N. Schoonen, J. Martijn, P. De-waal et al., dihydroxy-4-pregnen-3-one) stimulates early stages of spermatogenesis in zebrafish, Gen, vol.17, issue.466, pp.20-465

P. De-waal, M. Leal, A. Garcia-lopez, S. Liarte, H. De-jonge et al., Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis, Journal of Endocrinology, vol.202, issue.2, pp.287-29710, 2009.
DOI : 10.1677/JOE-09-0050

URL : https://hal.archives-ouvertes.fr/ineris-00963210

P. De-waal, D. Wang, W. Nijenhuis, R. Schulz, and J. Bogerd, Functional characterization and 472 expression analysis of the androgen receptor in zebrafish (Danio rerio) testis, Reproduction, vol.473, issue.2, pp.136225-23410, 1530.

N. Diotel, D. Rego, J. Anglade, I. Vaillant, C. Pellegrini et al., Activity and expression of steroidogenic enzymes in the brain of adult zebrafish. Eur 476, J Neurosci, vol.34, issue.1, pp.45-56, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00616835

H. Feitsma, M. Leal, P. Moens, E. Cuppen, and R. Schulz, Mlh1 Deficiency in Zebrafish Results in Male Sterility and Aneuploid as Well as Triploid Progeny in Females, Genetics, vol.175, issue.4, pp.1561-479, 2007.
DOI : 10.1534/genetics.106.068171

P. Forlano, D. Deitcher, D. Myers, and A. Bass, Anatomical distribution and cellular basis for 481 high levels of aromatase activity in the brain of teleost fish: Aromatase enzyme and mRNA 482 expression identify glia as source, J Neurosci, vol.21, issue.22, pp.8943-8955, 2001.

J. Bogerd and R. Schulz, Studies in Zebrafish Reveal Unusual Cellular Expression 488 Patterns of Gonadotropin Receptor Messenger Ribonucleic Acids in the Testis and 489 Unexpected Functional Differentiation of the Gonadotropins, Endocrinology, vol.151, issue.5, pp.2349-490, 2010.

N. Georgopapadakou, Antifungals: mechanism of action and resistance, established and novel drugs, Current Opinion in Microbiology, vol.1, issue.5, pp.547-55710, 1998.
DOI : 10.1016/S1369-5274(98)80087-8

M. Griswold, Interactions Between Germ Cells and Sertoli Cells in the Testis, Biology of Reproduction, vol.52, issue.2, pp.494211-216, 1995.
DOI : 10.1095/biolreprod52.2.211

M. Heneweer, M. Van-den-berg, and J. Sanderson, A comparison of human H295R and rat R2C cell 496 lines as in vitro screening tools for effects on aromatase, Toxicol Lett, vol.146, issue.2, 2004.

N. Hinfray, O. Palluel, C. Turies, C. Cousin, J. Porcher et al., Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish (Danio rerio), Environmental Toxicology, vol.63, issue.4, pp.332-337, 2006.
DOI : 10.1002/tox.20203

URL : https://hal.archives-ouvertes.fr/ineris-00961901

N. Hinfray, J. Porcher, and F. Brion, Inhibition of rainbow trout (Oncorhynchus mykiss) P450 509 aromatase activities in brain and ovarian microsomes by various environmental substances, p.510, 2006.

J. Huggett, K. Dheda, S. Bustin, and A. Zumla, Real-time RT-PCR normalisation; strategies and considerations, Genes and Immunity, vol.50, issue.4, pp.279-284, 2005.
DOI : 10.1038/sj.gene.6364190

M. Kahle, I. Buerge, A. Hauser, M. Muller, and T. Poiger, Azole Fungicides: Occurrence and Fate in Wastewater and Surface Waters, Environmental Science & Technology, vol.42, issue.19, pp.7193-7200, 2008.
DOI : 10.1021/es8009309

M. Kobayashi, M. Amano, M. Kim, Y. Yoshiura, Y. Sohn et al., Gonadotropin- 521 releasing hormone and gonadotropin in goldfish and masu salmon, Fish Physiology and Biochemistry, vol.17, issue.1/6, pp.1-8101007764430746, 1023.
DOI : 10.1023/A:1007764430746

J. Kreuger, Pesticides in stream water within an agricultural catchment in southern Sweden, Sci Total Environ, vol.524, issue.2163, pp.1990-1996, 1998.

T. Kumar, What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice?, Reproduction, vol.130, issue.3, pp.293-302, 2005.
DOI : 10.1530/rep.1.00660

A. Lee, M. Cai, P. Thomas, A. Conney, and B. Zhu, Characterization of the Oxidative Metabolites of 17??-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms, Endocrinology, vol.144, issue.8, pp.3382-3398, 2003.
DOI : 10.1210/en.2003-0192

L. Roy, C. Lejeune, H. Chuzel, F. Saez, J. Langlois et al., Autocrine regulation of Leydig cell 534 differentiated functions by insulin-like growth factor I and transforming growth factor beta, J, vol.535, 1999.

M. Loir, Spermatogonia of rainbow trout: II. in vitro study of the influence of pituitary hormones, growth factors and steroids on mitotic activity, 4<434::aid-mrd9>3.0.co, pp.434-442, 1999.
DOI : 10.1002/(SICI)1098-2795(199908)53:4<434::AID-MRD9>3.0.CO;2-L

Y. Lou, S. Qiao, R. Talonpoika, H. Syvala, and P. Tuohimaa, The role of Vitamin D3 metabolism in prostate cancer, The Journal of Steroid Biochemistry and Molecular Biology, vol.92, issue.4, pp.317-325, 2004.
DOI : 10.1016/j.jsbmb.2004.10.007

S. Matta, D. Vilela, H. Godinho, and L. Franca, ) Model, Endocrinology, vol.143, issue.3, pp.970-978, 2002.
DOI : 10.1210/endo.143.3.8666

R. Mclachlan, O. Donnell, L. Stanton, P. Balourdos, G. Frydenberg et al., Effects of testosterone plus medroxyprogesterone acetate on semen quality, p.20, 2002.

A. Menuet, E. Pellegrini, F. Brion, M. Gueguen, I. Anglade et al., Expression and 550 estrogen-dependent regulation of the zebrafish brain aromatase gene, J Comp Neurol, vol.485, issue.4, pp.551304-320, 2005.

W. Miller, Molecular Biology of Steroid Hormone Synthesis*, Endocrine Reviews, vol.9, issue.3, pp.295-318, 1988.
DOI : 10.1210/edrv-9-3-295

T. Miura, C. Miura, and K. Yamauchi, cDNA cloning of spermatogenesis relating substances and the 554 analysis of their functions in Japanese eel In: Perspective in Comparative Endocrinology: 555 Unity and Diversity, pp.969-976, 2001.

T. Miura, K. Yamauchi, H. Takahashi, and Y. Nagahama, Hormonal Induction of All Stages of 557, 1991.

G. Monod, A. Demones, and A. Fostier, Inhibition of ovarian microsomal aromatase and follicular oestradiol secretion by imidazole fungicides in Rainbow trout, Marine Environmental Research, vol.35, issue.1-2, pp.153-157, 1993.
DOI : 10.1016/0141-1136(93)90030-4

R. Nobrega, S. Batlouni, and L. Franca, An overview of functional and stereological evaluation of spermatogenesis and germ cell transplantation in fish, Fish Physiology and Biochemistry, vol.44, issue.1, pp.197-564, 2009.
DOI : 10.1007/s10695-008-9252-z

T. Ohta, H. Miyake, C. Miura, H. Kamei, K. Aida et al., Follicle-stimulating hormone induces 566 spermatogenesis mediated by androgen production in Japanese Eel, Anguilla japonica, Biol, vol.567, issue.776, pp.970-977, 2007.

K. Parker and B. Schimmer, Transcriptional Regulation of the Genes Encoding the Cytochrome P-450 Steroid Hydroxylases, Vitam Horm, vol.51, pp.339-370, 1995.
DOI : 10.1016/S0083-6729(08)61044-4

M. Pasmanik and G. Callard, Aromatase and 5-Alpha-Reductase in the Teleost Brain, Spinal-Cord, 571 and Pituitary-Gland, Gen Comp Endocrinol, vol.6085, issue.2, pp.244-25110, 1985.

M. Peschka, P. Roberts, and T. Knepper, Analysis, fate studies and monitoring of the antifungal agent clotrimazole in the aquatic environment, Analytical and Bioanalytical Chemistry, vol.38, issue.10, pp.959-968, 2007.
DOI : 10.1007/s00216-007-1480-z

C. Petersen and O. Soder, The Sertoli cell -A hormonal target and "Super" nurse for germ cells that 577 determines testicular size, Horm Res, vol.66, issue.4, pp.153-161, 2006.

J. Pierce and T. Parsons, Glycoprotein Hormones: Structure and Function, Annual Review of Biochemistry, vol.50, issue.1, pp.465-495, 1981.
DOI : 10.1146/annurev.bi.50.070181.002341

J. Planas, P. Swanson, and W. Dickhoff, Regulation of Testicular-Steroid Production in-Vitro by 581, 1993.

. Gonadotropins, Gth-I and Gth-Ii) and Cyclic-Amp in Coho Salmon (Oncorhynchus-Kisutch)

T. Plant and G. Marshall, The Functional Significance of FSH in Spermatogenesis and the Control of Its Secretion in Male Primates, Endocrine Reviews, vol.22, issue.6, pp.764-786, 2001.
DOI : 10.1210/edrv.22.6.0446

P. Roberts and K. Thomas, The occurrence of selected pharmaceuticals in wastewater effluent 586 and surface waters of the lower Tyne catchment, Sci Total Environ, vol.356, pp.1-3143, 2006.

I. Schuster, The Interaction of Representative Members from 2 Classes of Antimycotics -the 591, 1985.

C. Steven, N. Lehnen, K. Kight, S. Ijiri, U. Klenke et al., Molecular 594 characterization of the GnRH system in zebrafish (Danio rerio): cloning of chicken GnRH-II, 595 adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRH-II, 2003.

K. Thomas and M. Hilton, The occurrence of selected human pharmaceutical compounds in UK 598 estuaries, Mar Pollut Bull, vol.49, pp.5-6436, 2004.

D. Villeneuve, L. Blake, J. Brodin, K. Greene, I. Knoebl et al., Transcription of key genes regulating gonadal steroidogenesis in control and 601, p.600, 2007.

A. Linnum and G. Ankley, Development of quantitative real-time PCR assays for 605 fathead minnow (Pimephales promelas) gonadotropin beta subunit mRNAs to support 606 endocrine disruptor research, Com Biochem and Physiol C-Toxicology & Pharmacology, vol.145, issue.2, pp.607171-183, 2007.

A. Vinggaard, C. Hnida, V. Breinholt, and J. Larsen, Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro, Toxicology in Vitro, vol.14, issue.3, pp.227-23410, 2000.
DOI : 10.1016/S0887-2333(00)00018-7

D. Wang, B. Jiao, C. Hu, X. Huang, Z. Liu et al., Discovery of a gonad-specific 612 IGF subtype in teleost, Biochem Biophys Res Commun, vol.36712, issue.2, pp.336-341136, 2007.

X. Zhang, M. Hecker, P. Jones, J. Newsted, D. Au et al., Responses of 615 the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole, p.616, 2008.