Integrated testing and intelligent assessment???new challenges under REACH, Environmental Science and Pollution Research, vol.18, issue.11???12, pp.565-72, 2008. ,
DOI : 10.1007/s11356-008-0043-y
Mixture Toxicity Revisited from a Toxicogenomic Perspective, Environmental Science & Technology, vol.46, issue.5, pp.2508-2530, 2012. ,
DOI : 10.1021/es2038036
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment, Environmental Toxicology and Chemistry, vol.38, issue.3, pp.730-771, 2010. ,
DOI : 10.1002/etc.34
Predictive Environmental Risk Assessment of Chemical Mixtures: A Conceptual Framework, Environmental Science & Technology, vol.46, issue.5, pp.2564-73, 2012. ,
DOI : 10.1021/es2034125
Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology, Chemical Reviews, vol.111, issue.4, pp.2507-2543, 2011. ,
DOI : 10.1021/cr100222q
Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways, PLoS ONE, vol.13, issue.6, p.20887, 2011. ,
DOI : 10.1371/journal.pone.0020887.g006
Structural Alerts for the Excess Toxicity of Acrylates, Methacrylates, and Propiolates Derived from Their Short-Term and Long-Term Bacterial Toxicity, Chemical Research in Toxicology, vol.25, issue.1, pp.170-80, 2012. ,
DOI : 10.1021/tx200395k
The scientific assessment of combined effects of risk factors: different approaches in experimental biosciences and epidemiology, European Journal of Epidemiology, vol.115, issue.Suppl 1, pp.539-585, 2010. ,
DOI : 10.1007/s10654-010-9464-2
URL : https://hal.archives-ouvertes.fr/hal-00594928
Thiol Reactivity and Its Impact on the Ciliate Toxicity of ??,??-Unsaturated Aldehydes, Ketones, and Esters, Chemical Research in Toxicology, vol.23, issue.12, pp.1905-1917, 2010. ,
DOI : 10.1021/tx100226n
Critical analysis of literature on low dose synergy for use of TTC in screening chemical mixtures for risk assessment, Toxicology Letters, vol.189 ,
DOI : 10.1016/j.toxlet.2009.06.095
Peer Reviewed: Meeting the Scientific Needs of Ecological Risk Assessment in a Regulatory Context, Environmental Science & Technology, vol.38, issue.23, pp.463-70, 2004. ,
DOI : 10.1021/es040675s
Uncertainty in epidemiology and health risk and impact assessment, Environmental Geochemistry and Health, vol.4, issue.1207, pp.189-203, 2009. ,
DOI : 10.1007/s10653-008-9214-5
Inroads to Predict in Vivo Toxicology???An Introduction to the eTOX Project, International Journal of Molecular Sciences, vol.13, issue.12, pp.3820-3866, 2012. ,
DOI : 10.3390/ijms13033820
The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity, Regulatory Toxicology and Pharmacology, vol.67, issue.2, 2013. ,
DOI : 10.1016/j.yrtph.2013.01.002
Intelligent testing strategies for chemicals testing -a case of more haste, less speed?, ATLA, vol.33, pp.289-97, 2005. ,
Introduction to benchmark dose methods and U.S. EPA's benchmark dose software (BMDS) version 2.1.1, Toxicology and Applied Pharmacology, vol.254, issue.2, pp.181-91, 2011. ,
DOI : 10.1016/j.taap.2010.10.016
A Stepwise Approach for Defining the Applicability Domain of SAR and QSAR Models, Journal of Chemical Information and Modeling, vol.45, issue.4, pp.839-888, 2005. ,
DOI : 10.1021/ci0500381
Including social impact assessment in food safety governance, Food Control, vol.21, issue.12, pp.1620-1628, 2010. ,
DOI : 10.1016/j.foodcont.2009.05.007
The Lisbon Treaty : The readable version, p.36, 2009. ,
Health Council of the Netherlands) Prudent Precaution, 2008. ,
Factors influencing societal response of nanotechnology: an expert stakeholder analysis, Journal of Nanoparticle Research, vol.33, issue.4, p.857, 2012. ,
DOI : 10.1007/s11051-012-0857-x
Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective, Regulatory Toxicology and Pharmacology, vol.47, issue.1, pp.96-109, 2007. ,
DOI : 10.1016/j.yrtph.2006.08.004
A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study, Reproductive Toxicology, vol.24, issue.1 ,
DOI : 10.1016/j.reprotox.2007.05.004
Towards optimization of chemical testing under REACH: A Bayesian network approach to Integrated Testing Strategies, Regulatory Toxicology and Pharmacology, vol.57, issue.2-3, pp.157-67, 2010. ,
DOI : 10.1016/j.yrtph.2010.02.003
Computational Evidence for ??-Nitrosamino Radical as Initial Metabolite for Both the P450 Dealkylation and Denitrosation of Carcinogenic Nitrosamines, The Journal of Physical Chemistry B, vol.116, issue.2, pp.903-915, 2012. ,
DOI : 10.1021/jp206570n
Model and Mechanism: N-Hydroxylation of Primary Aromatic Amines by Cytochrome???P450, Angewandte Chemie International Edition, vol.7, issue.507, pp.744-792, 2013. ,
DOI : 10.1002/anie.201204116
A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data, Regulatory Toxicology and Pharmacology, vol.25, issue.1, pp.1-5, 1997. ,
DOI : 10.1006/rtph.1996.1076
State of the art report on mixture toxicity Contract study prepared for the European Commission, DG Environment, study contract no1; available online from the website of the European Commission at http, 2007. ,
Physiologically based pharmacokinetic modeling of chemical mixtures Toxicology of chemical mixtures: case studies, mechanisms and novel approaches, pp.399-437 ,
Chemical Domain of QSAR Models from Atom-Centered Fragments, Journal of Chemical Information and Modeling, vol.49, issue.12, pp.2660-2669, 2009. ,
DOI : 10.1021/ci900313u
Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens, Toxicology in Vitro, vol.25, issue.2, pp.433-478, 2011. ,
DOI : 10.1016/j.tiv.2010.11.007
Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework, Regul Toxicol Pharmacol, vol.60, pp.1-14, 2011. ,
Use of Genotoxicity Information in the Development of Integrated Testing Strategies (ITS) for Skin Sensitization, Chemical Research in Toxicology, vol.23, issue.10, pp.1519-1559, 2010. ,
DOI : 10.1021/tx100161j
Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations, Organic & Biomolecular Chemistry, vol.48, issue.24, pp.8400-8412, 2011. ,
DOI : 10.1039/c1ob06065a
Whole Body Pharmacokinetic Models, Clinical Pharmacokinetics, vol.15, issue.10, pp.883-908, 2003. ,
DOI : 10.2165/00003088-200342100-00002
Maximum-Likelihood Estimation of Predictive Uncertainty in Probabilistic QSAR Modeling, QSAR & Combinatorial Science, vol.48, issue.3, pp.338-382, 2009. ,
DOI : 10.1002/qsar.200860116
Substance-tailored testing strategies in toxicology: An in silico methodology based on QSAR modeling of toxicological thresholds and Monte Carlo simulations of toxicological testing, Regulatory Toxicology and Pharmacology, vol.56, issue.1, pp.82-92, 2010. ,
DOI : 10.1016/j.yrtph.2009.09.009
Binary weight-of-evidence evaluations of chemical interactions???15 years of experience, Regulatory Toxicology and Pharmacology, vol.54, issue.3, pp.264-71, 2009. ,
DOI : 10.1016/j.yrtph.2009.05.003
An integrated QSAR???PBPK modelling approach for predicting the inhalation toxicokinetics of mixtures of volatile organic chemicals in the rat, SAR and QSAR in Environmental Research, vol.19, issue.1-2, pp.107-135, 2011. ,
DOI : 10.1006/taap.1994.1180
Assessing toxicological data quality: basic principles, existing schemes and current limitations, SAR and QSAR in Environmental Research, vol.42, issue.5-6, pp.435-59, 2012. ,
DOI : 10.1016/j.tox.2005.05.014
Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice, Regulatory Toxicology and Pharmacology, vol.61, pp.105-119, 2011. ,
DOI : 10.1016/j.yrtph.2011.06.007
Toward Better Exposure Assessment Strategies?The New NIOSH Initiative, Ann Occup Hyg, vol.52, pp.297-301, 2008. ,
Anticipating the perceived risk of nanotechnologies, Nature Nanotechnology, vol.1, issue.11, pp.752-58, 2009. ,
DOI : 10.1038/nnano.2009.265
Improvement if Risk Assessment in View of the Needs of Risk Managers and Policy Makers, 2011. ,
ToxRTool", a new tool to assess the reliability of toxicological data ,
: Structural Alerts Indicating Excess Toxicity, Environmental Science & Technology, vol.45, issue.13, pp.5812-5821, 2011. ,
DOI : 10.1021/es200081n
Assessing Applicability Domains of Toxicological QSARs: Definition, Confidence in Predicted Values, and the Role of Mechanisms of Action, QSAR & Combinatorial Science, vol.45, issue.2, pp.238-54, 2007. ,
DOI : 10.1002/qsar.200630020
External Validation and Prediction Employing the Predictive Squared Correlation Coefficient ??? Test Set Activity Mean vs Training Set Activity Mean, Journal of Chemical Information and Modeling, vol.48, issue.11, pp.2140-2145, 2008. ,
DOI : 10.1021/ci800253u
Quantitative Read-Across for Predicting the Acute Fish Toxicity of Organic Compounds, Environmental Science & Technology, vol.45, issue.10, pp.4616-4638, 2011. ,
DOI : 10.1021/es200361r
Predicting faterelated physicochemical properties Risk assessment of chemicals: An Introduction. 2 nd Edition, pp.375-426, 2007. ,
Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology, Chemical Reviews, vol.111, issue.4, pp.2562-96, 2011. ,
DOI : 10.1021/cr100098n
An empirical hierarchical Bayesian unification of occupational exposure assessment methods, Statistics in Medicine, vol.45, issue.3, pp.75-93, 2009. ,
DOI : 10.1002/sim.3411
A Critical Evaluation of the 2011 ECHA Reports on Compliance with the REACH and CLP Regulations and on the Use of Alternatives to Testing on Animals for Compliance with the REACH Regulation, ATLA, pp.481-93, 2011. ,
A Kernel-Based Method for Assessing Uncertainty on Individual QSAR Predictions, Molecular Informatics, vol.87, issue.10, pp.741-51, 2012. ,
DOI : 10.1002/minf.201200053
URL : https://hal.archives-ouvertes.fr/ineris-00963395
Chemoassay Screening of DNA-Reactive Mutagenicity with 4-(4-Nitrobenzyl)pyridine?????????Application to Epoxides, Oxetanes, and Sulfur Heterocycles, Chemical Research in Toxicology, vol.25, issue.10, pp.2092-2102, 2012. ,
DOI : 10.1021/tx3001412
Tautomer Identification and Tautomer Structure Generation Based on the InChI Code, Journal of Chemical Information and Modeling, vol.50, issue.7, pp.1223-1255, 2010. ,
DOI : 10.1021/ci1001179
Tools for regulatory assessment of occupational exposure: development and challenges, Journal of Exposure Science and Environmental Epidemiology, vol.28, pp.72-80, 2007. ,
DOI : 10.1038/sj.jes.7500604
The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS), Regulatory Toxicology and Pharmacology, vol.67, issue.2 ,
DOI : 10.1016/j.yrtph.2013.02.004
A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling, Environmental Health Perspectives, vol.105, issue.Suppl 1, pp.179-95, 1997. ,
DOI : 10.1289/ehp.97105s1179
From risk assessment to environmental impact assessment of chemical substances, Methodology development to be used in socio-economic analysis for REACH ,
Structural AlertsA New Classification Model to Discriminate Excess Toxicity from Narcotic Effect Levels of Organic Compounds in the Acute Daphnid Assay, Chemical Research in Toxicology, vol.18, issue.3, pp.536-55, 2005. ,
DOI : 10.1021/tx0497954
Refinements of environmental risk assessment outputs for use in socioeconomic impact assessment under REACH, Report for the Luxembourg Environment Agency, 2011. ,
Weight of Evidence: A Review of Concept and Methods, Risk Analysis, vol.181, issue.182, pp.1545-57, 2005. ,
DOI : 10.1111/j.1539-6924.2005.00699.x