S. Française-de-santé-publique, La pollution atmosphérique d'origine automobile et la santé publique. Bilan de 15 ans de recherche internationale, Collection santé et société, vol.4, p.251, 1996.

M. Dj and R. Rm, Health effects associated with ozone and nitrogen dioxide exposure, Water Air Soil Pollut, vol.67, pp.11-35, 1993.

O. Jw, G. Lj, and Z. Yc, Studies on the enhancement of allergic lung sensitization by inhalation of ozone and sulfuric acid aerosol, J Environ Pathol Toxicol, vol.3, pp.221-255, 1980.

Y. H. , O. T. , A. T. , O. H. , S. K. et al., Ozone increases susceptibility to antigen inhalation in allergic dogs, J Appl Physiol, vol.68, pp.2267-73, 1990.

M. Na, W. Sc, K. I. , T. S. Silverman-f, . Mc et al., Effect of low concentrations of ozone on inhaled allergen responses in asthmatic subjects, Lancet, vol.338, pp.199-203, 1991.

B. Ba, F. Lj, P. Db, and K. Hr, Allergen bronchoprovocation of patients with mild allergic asthma after ozone exposure, J Allergy Clin Immunol, vol.98, pp.563-72, 1996.

B. R. , N. Rm, F. Tk, K. A. , and P. D. , Effects of ozone inhalation on the response to nasal challenge with antigen of allergic subjects, Am Rev Respir Dis, vol.142, pp.594-601, 1990.

P. G. , D. L. , and C. Mt, Models treatments simulating environmental action on allergenic Dactylis glomerata pollen, Grana, vol.30, pp.59-61, 1991.

M. G. , S. K. , F. Jt, M. H. , and B. Kc, Histological alterations and increase of group 5 allergen in anthers and pollens of Lolium perenne caused by ozone, Eur Resp J, vol.10, p.246, 1997.

G. J. Van-bree-l, . Van-der, . Vliet-h, and . Van, Ozone-induced impairment of pulmonary type IV hypersensitivity and airway hyperresponsiveness in mice, Inhal Toxicol, vol.9, pp.581-99, 1997.

S. He, Evaluation of the hazards of ozone and oxides of nitrogen, Arch Ind Health, vol.15, pp.181-90, 1957.

M. Fj, I. Jw, and G. De, Effect of urban ozone levels on laboratory-induced respiratory infections, Toxicol Lett, vol.2, pp.163-172, 1978.

G. Mi and S. Mk, A comparison of the pulmonary defenses against streptococcal infection in rats and mice following O 3 exposure : differences in disease susceptibility and neutrophil recruitment, Toxicol Appl Pharmacol, vol.123, pp.211-219, 1993.

G. Mi, P. P. , and S. Mk, Ozone-enhanced pulmonary infection with Streptococcus zooepidemicus in mice. The role of alveolar macrophage function and capsular virulence factors, Am Rev Respir Dis, vol.147, pp.753-60, 1993.

G. Mi, P. P. , D. D. , and S. Mk, Factors that influence the suppression of pulmonary antibacterial defenses in mice exposed to ozone, Exp Lung Res, vol.19, pp.299-314, 1993.

G. Mi, H. Rr, S. Ea, and J. Gj, Suppression and recovery of the alveolar macrophage phagocytic system during continuous exposure to 0.5 ppm ozone, Exp Lung Res, vol.17, pp.547-58, 1991.

A. C. , V. Sc, T. Pt, B. Jn, and F. Jd, Effects of subchronic exposure to a mixture of O 3 , SO 2 , and (NH 4 ) 2 SO 4 on host defenses of mice, J Toxicol Environ Health, vol.12, pp.55-71, 1983.

T. Gb, F. Jd, E. R. , and G. De, Effects of exposure to ozone on susceptibility to experimental tuberculosis, Toxicol Lett, vol.9, pp.11-18, 1981.

R. Van-loveren-h, W. Pja, W. Ss, V. Hc, and . Jg, Effects of ozone on the defense to a respiratory Listeria monocytogenes infection in the rat, Toxicology and Applied Pharmacology, vol.94, issue.3, pp.374-93, 1988.
DOI : 10.1016/0041-008X(88)90279-7

H. Fw, D. Ej, H. S. Seal-e, and G. D. , Experimental rhinovirus infection in human volunteers exposed to ozone, Am Rev Respir Dis, vol.137, issue.5, pp.1124-1132, 1988.

S. Mk, I. Jw, S. Dm, S. Ag, M. Mg et al., Evaluation of effects of ozone exposure on influenza infection in mice using several indicators of susceptibility, Fund Appl Toxicol, vol.11, pp.169-80, 1988.

S. J. , K. Hs, and . Becker-s, Ozone effect on respiratory syncitial virus infectivity and cytokine production by human alveolar macrophages, Environ Res, vol.60, pp.178-86, 1993.

J. Gj, S. Ew, C. Bj, K. Sr, and G. Mi, The effects of ozone on immune function, Environ Health Perspect, vol.103, issue.2, pp.77-89, 1995.

B. Ga, G. S. Sills-rc, H. R. Miller-ra, and H. Ra, Long-term toxicity studies of ozone in F344/N rats and B6C3F1 mice, Toxicol Lett, vol.8283, pp.301-307, 1995.

S. Rc, H. Hl, G. A. , H. R. Boorman-ga, and D. Tr, Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months, Carcinogenesis, vol.16, issue.7, pp.1623-1631, 1995.

M. G. , M. Jp, F. P. Morin-m, T. J. , and M. R. , Etude des effets cancérogènes et cocancérogènes de l'ozone chez le rat : résultats préliminaires, Pollut Atmos, pp.84-92, 1994.

A. Os, S. Bs, and B. Mk, A possible autoimmune parathyroiditis following ozone inhalation. II. A histopathologic, ultrastructural and immunofluorescent study, Am J Pathol, vol.79, pp.53-68, 1975.

D. D. and W. Hj, Thymus and pulmonary lymph node response to acute and subchronic ozone inhalation in the mouse, Environ Res, vol.41, pp.598-609, 1986.

B. Mr and D. D. , An immunofluorescence study of T and B lymphocytes in ozoneinduced pulmonary lesions in the mouse, Toxicol Appl Pharmacol, vol.105, pp.93-102, 1990.

G. Mi and J. Gj, Modulation of immune function in mice exposed to 0.8 ppm ozone, Inhal Toxicol, vol.3, pp.293-308, 1991.

L. Afy and R. A. , Ambient levels of ozone effects on subpopulations of thymocytes and spleen T lymphocytes, Arch Environ Health, vol.46, issue.1, pp.57-63, 1991.

B. Mr, S. Ne, and D. D. , Effects of cyclosporine A on ozone-induced pulmonary lesion formation: pharmacologic elimination of the T-lymphocyte regulatory response, Arch Environ Contam Toxicol, vol.28, pp.240-247, 1995.

D. D. and W. Hj, T-cell activation in pulmonary lymph nodes of mice exposed to ozone, Environ Res, vol.41, pp.610-632, 1986.

D. D. and W. Hj, Response of T-cell-deficient mice to ozone exposure, J Toxicol Environ Health, vol.21, pp.57-71, 1987.

S. Mk, D. Mj, and . Ec, Acute, subchronic, and chronic exposure to a simulated urban profile of ozone: effects on extrapulmonary natural killer cell activity and lymphocyte mitogenic responses, Inhal Toxicol, vol.2, pp.375-89, 1990.

H. Ja, H. Jr, K. Dt, and H. Rf, Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure, Exp Lung Res, vol.15, pp.1-16, 1989.

K. Sr, L. Rc, and Z. Ly, Susceptibility to ozone-induced inflammation. I. Genetic control of the response to subacute exposure, Am J Physiol, vol.264, issue.1, pp.15-20, 1993.

S. Ah and B. Djp, Guinea pig lung inflammatory cell changes following acute ozone exposure, Lung, vol.172, pp.169-81, 1994.

K. Hs, . Devlin-rb, P. R. Becker-s, and M. Wf, Time-dependent changes of markers associated with inflammation in the lungs of humans exposed to ambient levels of ozone, Toxicol Pathol, vol.19, issue.1, pp.406-417, 1991.

D. Rb, M. Wf, M. Becker-s, M. Mc, P. R. Mp et al., Time-dependant changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure, Toxicol Appl Pharmacol, vol.138, pp.176-85, 1996.

L. H. Tyler-ws, H. Dm, and P. Cg, Morphometry of in situ and lavaged pulmonary alveolar macrophages from control and ozone-exposed rats, Exp Lung Res, vol.5, pp.61-78, 1983.

W. , G. , A. Ma, and G. Bd, Effect of ozone on alveolar macrophage function: membrane dynamic properties, Advan Mod Environ Toxicol, vol.5, pp.263-72, 1983.

D. Jama, R. Pja, and . Van, Surface morphology and morphometry of rat alveolar macrophages after ozone exposure, J Toxicol Environ Health, vol.31, pp.53-70, 1990.

C. Dl, G. Ms, H. Rs, and W. Fj, Influence of ozone on pulmonary cells, Arch Environ Health, vol.16, pp.633-639, 1968.

B. Goldstein-e, . Hc, . Van-der-ploeg-m, . Van-duijn-p, . Van-der-stap et al., Effect of Ozone on Lysosomal Enzymes of Alveolar Macrophages Engaged in Phagocytosis and Killing of Inhaled Staphylococcus aureus, Journal of Infectious Diseases, vol.138, issue.3, pp.299-311, 1978.
DOI : 10.1093/infdis/138.3.299

S. Rb, Z. Jt, C. Chen-l, and K. Pl, Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures, Toxicol Appl Pharmacol, vol.115, pp.183-90, 1992.

D. Ke, V. Ta, and S. Rb, Acute and subchronic ozone inhalation in the rabbit: response of alveolar macrophages, J Toxicol Environ Health, vol.21, pp.27-43, 1987.

C. Ca and S. Lw, Enhanced phagocytosis by alveolar macrophages induced by short-term ozone insult, Environ Res, vol.28, pp.241-50, 1982.

O. Rs, . Van-golde, V. J. Lmg, and . Van-bree-l, Species differences in impairment and recovery of alveolar macrophages functions following single and repeated ozone exposures, Toxicol Appl Pharmacol, vol.110, pp.170-178, 1991.

C. Bj, H. Rr, S. Ew, and J. Gj, Ozone reduces murine alveolar and peritoneal macrophage phagocytosis: the role of prostanoids, Am J Physiol, vol.261, pp.277-82, 1991.

W. Dg and M. Dl, In vitro inhibition of alveolar macrophage phagocytosis by ozone: absence of a role for serum or mode of ozone administration, Toxicol Lett, vol.18, pp.57-61, 1983.

M. Becker-s, N. Mc, . Sl, K. Devlin-rb, and . Hs, Modulation of human alveolar macrophage properties by ozone exposure in vitro, Toxicology and Applied Pharmacology, vol.110, issue.3, pp.403-418, 1991.
DOI : 10.1016/0041-008X(91)90042-D

C. L. Chen, Q. Q. , A. Mo, and S. Rb, Alteration of Pulmonary Macrophage Intracellular PH Following Inhalation Exposure to Sulfuric Acid/Ozone Mixtures, Experimental Lung Research, vol.147, issue.4, pp.113-141, 1995.
DOI : 10.1021/tx00021a014

H. Dj, G. De, and C. Dl, Effect of ozone on acid hydrolases of the pulmonary alveolar macrophage, J Reticuloendothelial Soc, vol.8, pp.288-300, 1970.

Z. Jt, P. E. Sisco-m, T. D. , Y. Zj, and S. Rb, Inhaled air pollutants disrupt macrophage-mediated immunity in the lung, Toxicologist, vol.12, p.46, 1992.

S. Rb, E. Han, G. Zelikoff-jt, . Je, N. Mcgovern-t et al., Pulmonary effects of repeated episodic exposures to nitric acid vapor alone and in combination with ozone, Inhal Toxicol, vol.6, pp.21-41, 1994.

S. Rl, L. We, and . Goldstein-e, Effect of 0.64 ppm ozone on alveolar macrophage lysozyme levels in rats with chronic pulmonary bacterial infection, Environ Res, vol.41, pp.378-87, 1986.

I. Al, C. Zee-y, and O. Jw, The effects of ozone on the respiratory epithelium and alveolar macrophages of mice. I. Interferon production, Proc Soc Exp Biol Med, vol.152, pp.483-491, 1976.

P. Kj, . Shuler-rl, L. Laskin-jd, and . Dl, Enhanced production of interleukin-1, tumor necrosis factor-and fibronectin by rat lung phagocytes following inhalation of a pulmonary irritant, Am J Respir Cell Mol Biol, vol.11, pp.279-86, 1994.

A. K. , G. P. , V. D. , V. C. , H. Q. et al., Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro, Am J Respir Cell Mol Biol, vol.13, pp.60-68, 1995.

D. Ke and S. Rb, Alveolar macrophage-stimulated neutrophil and monocyte migration : effects of in vitro ozone exposure, Toxicol Appl Pharmacol, vol.93, pp.312-320, 1988.

O. Jw, O. Sl, C. Zee-y, D. Wm, and L. Dd, Immunological alterations in the lungs of mice following ozone exposure: changes in immunoglobulin levels and antibody-containing cells, Arch Environ Health, pp.258-65, 1979.

P. Ml, S. R. , H. S. , K. B. , and H. D. , The effect of controlled ozone exposure on human lymphocyte function, Environ Res, vol.24, pp.299-308, 1981.

O. Gs, H. D. , D. Eg, K. Hs, and . Becker-s, Effect of ozone on T-cell proliferation and serum levels of beta-endorphin in exercising males, Inhal Toxicol, vol.1, pp.53-63, 1988.

J. R. Becker-s and O. Gs, In vitro ozone exposure inhibits mitogen???induced lymphocyte proliferation and IL???2 production, Journal of Toxicology and Environmental Health, vol.52, issue.4, pp.469-83, 1989.
DOI : 10.1016/0008-8749(85)90262-X

E. Ml, S. Wj, S. Rw, R. Cc, and Z. A. , The effects of ozone inhalation on the immunological response of selenium-and vitamin E-deprived rats, Environ Res, vol.40, pp.274-84, 1986.

Q. J. Becker-s and K. Hs, Effect of ozone on immunoglobulin production by human b cells in vitro, Journal of Toxicology and Environmental Health, vol.60, issue.3, pp.353-66, 1991.
DOI : 10.1084/jem.162.5.1726

K. Van-loveren-h, R. Ei, B. Pja, V. Fa, and . Jg, Effects of ozone, hexachlorobenzene, and bis(tri-n-butyltin)oxide on natural killer activity in the rat lung, Toxicology and Applied Pharmacology, vol.102, issue.1, pp.21-33, 1990.
DOI : 10.1016/0041-008X(90)90080-E

B. Gr, K. Ll, and S. Jd, Immunosuppression of pulmonary natural killer activity by exposure to ozone, Immunopharmacol Immunotoxicol, vol.11, issue.4, pp.715-750, 1989.

H. Dh, H. Dt, H. D. , and K. Hs, Inhibition of human natural killer cell activity following in vitro exposure to ozone, Inhal Toxicol, vol.2, pp.161-73, 1990.

S. Van-loveren-h, G. J. Pa, and . Van-bree-l, Interaction of environmental chemicals with respiratory sensitization, Toxicology Letters, vol.86, issue.2-3, pp.163-170, 1996.
DOI : 10.1016/0378-4274(96)03686-7

H. Me, H. R. , H. A. , and E. Wl, Ozone-induced increases in substance P and 8-epi-prostaglandin F 2 in the airways of human subjects, Amer J Respir Cell Molec Biol, vol.9, pp.568-72, 1993.

P. Ml, R. N. Harder-s, and H. D. , Effect of ozone on leukocytes function in exposed human subjects, Environ Res, vol.15, pp.485-93, 1978.

W. Pa and S. Rb, Effect on in vitro exposure to ozone on eicosanoid metabolism and phagocytic activity of human and rabbit neutrophils, Inhal Toxicol, vol.6, pp.43-55, 1994.

P. Db and D. L. , Modulation of mast cell functions by in vitro exposure, Am J Physiol, vol.268, pp.902-912, 1995.

H. Ge, S. R. , S. Ag, and G. J. , Species comparison of acute inhalation toxicity of ozone and phosgene, J Toxicol Environ Health, vol.19, pp.43-53, 1986.

D. X. , B. Ar, J. C. Pinkerton-ke, and P. Cg, Ozone-induced alterations in glutatione in lung subcompartments of rats and monkeys, Amer J Respir Cell Molec Biol, vol.14, pp.70-75, 1996.

P. Mv, H. Dm, and S. My, Strain differences in the response of the rat lung to an acute ozone exposure, Am Rev Respir Dis, vol.143, issue.42, p.91, 1991.

W. Wp, H. Jw, S. R. , and H. Ge, Ozone toxicity in the mouse: comparison and modeling of responses in susceptible and resistant strains, J Appl Physiol, vol.80, issue.6, pp.2134-2176, 1996.

K. K. , M. M. , H. G. , C. D. , and D. Rb, Inflammatory effects of ozone exposure in juvenile rats of three strains, Am J Respir Crit Care Med, vol.151, issue.4 2, 1995.

D. Jama, B. Ajf, R. Van-loveren-h, M. M. Pja, and . Van-bree-l, Age-related toxicity in rat lungs following acute and repeated ozone exposure, Inhal Toxicol, vol.8, pp.903-928, 1996.

V. R. Vu-d, H. G. Poon-r, D. K. , G. J. , B. S. et al., Sensitivity of lung of aging Fischer 344 rats to ozone: assessment by bronchoalveolar lavage, Am J Physiol, vol.271, pp.555-65, 1996.

W. Wp, M. Lyon-jy, N. J. Jl, D. Dl, H. Ge et al., Dosimetric, physiological, and biochemecal effects of ozone exposure during treadmill exercise and CO 2 -stimulated ventilation in the rat, Am J Respir Crit Care Med, vol.151, issue.4 2, p.496, 1995.

G. Af, H. Ge, and C. K. Bowers-a, Comparative sensitivity of lactating and virgin female rats to ozone-induced pulmonary inflammation, Inhal Toxicol, vol.8, pp.607-630, 1996.

M. T. and A. Wc, Pulmonary function response to equivalent doses of ozone consequent to intermittent and continuous exercise, Arch Environ Health, vol.50, issue.2, pp.153-161, 1995.

W. Mj, C. Watkinson-wp, C. Dl, R. Km, W. Jh et al., Ozone toxicity in the rat. III. Effect of changes in ambient temperature on pulmonary parameters, J Appl Physiol, vol.81, issue.4, pp.1691-700, 1996.

V. L. Bree, M. M. , and R. Pja, Differences in pulmonary biochemical and inflammatory responses of rats and guinea pigs resulting from daytime or nighttime, single and repeated exposure to ozone, Toxicology and Applied Pharmacology, vol.116, issue.2, pp.209-225, 1992.
DOI : 10.1016/0041-008X(92)90300-H

L. Ec and R. Ga, Reduced growth in rats exposed to ozone as compared to pair-fed controls breathing air, IRCS Med Sci, vol.12, pp.741-743, 1984.