Applications of population approaches in toxicology - Archive ouverte HAL Access content directly
Journal Articles Toxicology Letters Year : 2001

Applications of population approaches in toxicology

(1)
1

Abstract

Many experimental or observational studies in toxicology are best analysed in a population framework. Recent examples include investigations of the extent and origin of intra-individual variability in toxicity studies, incorporation of genotypic information to address intra-individual variability, optimal design of experiments, and extension of toxicokinetic modelling to the analysis of biomarker studies. Bayesian statistics provide powerful numerical methods for fitting population models, particularly when complex mechanistic models are involved. Challenges and limitations to the use of population models, in terms of basic structure, computational burden, ease of implementation and data accessibility, are identified and discussed.
Fichier principal
Vignette du fichier
2000-044b_post-print.pdf (210.77 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

ineris-00961855 , version 1 (20-03-2014)

Identifiers

Cite

Frédéric Y. Bois. Applications of population approaches in toxicology. Toxicology Letters, 2001, 120 (1-3), pp.385-394. ⟨10.1016/S0378-4274(01)00270-3⟩. ⟨ineris-00961855⟩

Collections

INERIS
47 View
331 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More