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Journal articles
Interference of a short-term exposure to nitrogen dioxide with allergic airways responses to allergenic challenges in BALB/c mice
Abstract : Nitrogen dioxide (NO2) is a common indoor and outdoor air pollutant whose role in the induction of asthma is unclear. We investigated the effects of NO2 on the development of asthma-like responses to allergenic challenge in BALB/c mice. Ovalbumin (OVA)-immunized mice were intranasally challenged with OVA or saline solution just before starting a 3 h exposure to 5 or 20 ppm NO2 or air. Twenty parts per million of NO2 induced a significant increase of bronchopulmonary hyperreactivity in OVA-challenged mice and of permeability according to the fibronectin content of the bronchoalveolar lavage fluid (BALF) 24 h after exposure, as compared with air or 5 ppm NO2. Eosinophilia (cell counts in the BALF and eosinophil peroxidase of lung tissue) was detected at 24 and 72 h with similar levels for air and 20 ppm NO2, whereas a marked reduction was unexpectedly observed for 5 ppm NO2. At 24 h, interleukin-5 in the BALF was markedly reduced at 5 ppm compared with 20 ppm NO2 and was also more intense for 20 ppm NO2 than for the air group. In contrast to specific IgG1 titers, anti-OVA IgE titers and interleukin-4 in the BALF were not affected by NO2 exposure. Irrespective of the concentration of NO2, OVA-challenged mice did not develop late mucosal metaplasia compared with those exposed to OVA-air. These results indicate that a short exposure to NO2 can exacerbate or inhibit some features of the development of allergic disease in mice and may depend on the concentration of pollutant.
Cited literature [40 references]
https://hal-ineris.archives-ouvertes.fr/ineris-00961866
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Submitted on : Thursday, March 20, 2014 - 3:26:52 PM
Last modification on : Friday, April 26, 2019 - 3:55:09 PM
Long-term archiving on: : Friday, June 20, 2014 - 12:10:11 PM
Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Thursday, March 20, 2014 - 3:26:52 PM
Last modification on : Friday, April 26, 2019 - 3:55:09 PM
Long-term archiving on: : Friday, June 20, 2014 - 12:10:11 PM
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