G. Thomas, P. Sandouk, C. Girre, and J. Scherrmann, Toxicocinétique des substances chimiques In: Encyclopédie Médico-Chirurgicale, Editions Techniques, pp.16-17, 1995.

L. Gray, C. Wolf, P. Mann, and J. Ostby, -tetrachlorodibenzo-p- dioxin alters reproductive development of female Long Evans hooded rat offspring, utero exposure to low doses of 2, pp.237-281, 1997.
URL : https://hal.archives-ouvertes.fr/jpa-00209836

G. Van-der-molen, S. Kooijman, and W. Slob, A Generic Toxicokinetic Model for Persistent Lipophilic Compounds in Humans: An Application to TCDD, Toxicological Sciences, vol.31, issue.1, pp.83-94, 1996.
DOI : 10.1093/toxsci/31.1.83

C. Schlatter, Data on kinetics of PCDDs and PCDFs as a prerequisite for human risk assessment, Biological Basis for Risk Assessments of Dioxins and Related Compounds, pp.215-243, 1991.

J. Pirkle, W. Wolfe, and D. Patterson, -tetrachlorodibenzo-p- dioxin in Vietnam veterans of Operation Ranch Hand, Journal of Toxicology and Environmental Health, vol.237, issue.27, pp.165-71, 1989.
URL : https://hal.archives-ouvertes.fr/hal-01442568

W. Wolfe, J. Michalek, and J. Miner, Determinants of TCDD half???life in veterans of operation ranch hand, Journal of Toxicology and Environmental Health, vol.37, issue.4, pp.481-489, 1994.
DOI : 10.1001/jama.264.14.1824

J. Michalek, J. Pirkle, S. Caudill, R. Tripathi, D. Patterson et al., PHARMACOKINETICS OF TCDD IN VETERANS OF OPERATION RANCH HAND: 10-YEAR FOLLOW-UP, Journal of Toxicology and Environmental Health, vol.47, issue.3, pp.209-229, 1996.
DOI : 10.1080/009841096161744

K. Thomaseth and A. Salvan, Estimation of occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin using a minimal physiologic toxicokinetic model, Environmental Health Perspectives, vol.106, issue.Suppl 2, pp.743-53, 1998.
DOI : 10.1289/ehp.98106743

J. Michalek and R. Tripathi, PHARMACOKINETICS OF TCDD IN VETERANS OF OPERATION RANCH HAND: 10-YEAR FOLLOW-UP, Journal of Toxicology and Environmental Health, vol.47, issue.3, pp.369-78, 1999.
DOI : 10.1080/009841096161744

H. Leung, R. Ku, D. Paustenbach, and M. Andersen, A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice, Toxicology Letters, vol.42, pp.15-28, 1988.

J. Kissel and G. Robarge, Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model, Chemosphere, vol.17, issue.10, pp.2017-2044, 1988.
DOI : 10.1016/0045-6535(88)90012-4

H. Leung, D. Paustenbach, F. Murray, and M. Andersen, A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat, Toxicology and Applied Pharmacology, vol.103, issue.3, pp.399-410, 1990.
DOI : 10.1016/0041-008X(90)90313-J

H. Leung, A. Poland, D. Paustenbach, F. Murray, and M. Andersen, Pharmacokinetics of [125I]-2-lodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach, Toxicology and Applied Pharmacology, vol.103, issue.3, pp.411-420, 1990.
DOI : 10.1016/0041-008X(90)90314-K

M. Kohn, G. Lucier, G. Clark, C. Sewall, A. Tritscher et al., A Mechanistic Model of Effects of Dioxin on Gene Expression in the Rat Liver, Toxicology and Applied Pharmacology, vol.120, issue.1, pp.138-54, 1993.
DOI : 10.1006/taap.1993.1096

L. Kedderis, J. Mills, M. Andersen, and L. Birnbaum, A Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction, Toxicology and Applied Pharmacology, vol.121, issue.1, pp.87-98, 1993.
DOI : 10.1006/taap.1993.1132

G. Carrier, R. Brunet, and J. Brodeur, Modeling of the Toxicokinetics of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Mammalians, Including Humans I. Nonlinear Distribution of PCDD/PCDF Body Burden between Liver and Adipose Tissues, Toxicology and Applied Pharmacology, vol.131, issue.2, pp.253-66, 1995.
DOI : 10.1006/taap.1995.1068

G. Carrier, R. Brunet, and J. Brodeur, Modeling of the Toxicokinetics of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Mammalians, Including Humans II. Kinetics of Absorption and Disposition of PCDDs/PCDFs, Toxicology and Applied Pharmacology, vol.131, issue.2, pp.267-76, 1995.
DOI : 10.1006/taap.1995.1069

M. Kohn, C. Sewall, G. Lucier, and C. Portier, A Mechanistic Model of Effects of Dioxin on Thyroid Hormones in the Rat, Toxicology and Applied Pharmacology, vol.136, issue.1, pp.29-48, 1996.
DOI : 10.1006/taap.1996.0004

S. Kelley, C. Nilsson, M. Green, J. Green, and H. Hakansson, Use of model-based compartmental analysis to study effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A kinetics in rats, Toxicological Sciences, vol.44, pp.1-13, 1998.

M. Andersen, J. Mills, and M. Gargas, Modeling Receptor-Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment, Risk Analysis, vol.11, issue.1, pp.25-36, 1993.
DOI : 10.1016/0045-6535(89)90430-X

C. Campbell, K. Teschke, J. Bert, P. Quintana, and C. Hertzman, Pharmacokinetic model of dioxin and furan levels in adipose tissue from Sawmill work involving chlorophenate fungicides, Chemosphere, vol.33, issue.12, pp.2373-81, 1996.
DOI : 10.1016/S0045-6535(96)00341-4

G. Lawrence and F. Gobas, A pharmacokinetic analysis of interspecies extrapolation in dioxin risk assessment, Chemosphere, vol.35, issue.3, pp.427-52, 1997.
DOI : 10.1016/S0045-6535(97)00108-2

M. Andersen, C. Eklund, J. Mills, H. Barton, and L. Birnbaum, A Multicompartment Geometric Model of the Liver in Relation to Regional Induction of Cytochrome P450s, Toxicology and Applied Pharmacology, vol.144, issue.1, pp.135-179, 1997.
DOI : 10.1006/taap.1996.8066

M. Andersen, L. Birnbaum, H. Barton, and C. Eklund, Regional Hepatic CYP1A1 and CYP1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin Evaluated with a Multicompartment Geometric Model of Hepatic Zonation, Toxicology and Applied Pharmacology, vol.144, issue.1, pp.145-55, 1997.
DOI : 10.1006/taap.1996.8067

J. Michalek, R. Tripathi, S. Caudill, and J. Pirkle, Investigation of TCDD half-life heterogeneity in veterans of Operation Ranch Hand [published erratum appeared in the, Journal of Toxicology and Environmental Health Journal of Toxicology and Environmental Health, vol.36, issue.35, pp.29-38, 1992.

G. Van-der-molen, S. Kooijman, J. Michalek, and W. Slob, The estimation of elimination rates of persistent compounds: A re-analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans, Chemosphere, vol.37, issue.9-12, pp.1833-1877, 1998.
DOI : 10.1016/S0045-6535(98)00249-5

F. Bois and B. Eskenazi, Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin, Environmental Health Perspectives, vol.102, issue.5, pp.476-483, 1994.
DOI : 10.1289/ehp.94102476

F. Bois and P. Bernillon, Transposer de l'animal à l'humain : les modèles pharmacocinétiques physiologiques In: Science et Décision en Santé Environnementale -Les Enjeux de l'Evaluation et de la Gestion des Risques, pp.127-165, 1996.

A. Bailer and D. Dankovic, An introduction to the use of physiologically based pharmacokinetic models in risk assessment, Statistical Methods in Medical Research, vol.91, issue.4, pp.341-58, 1997.
DOI : 10.1177/096228029700600404

F. Bois, Analysis of PBPK Models for Risk Characterization, Annals of the New York Academy of Sciences, vol.43, issue.9, pp.317-354, 1999.
DOI : 10.1016/0041-008X(90)90037-U

URL : https://hal.archives-ouvertes.fr/ineris-00962759

L. Gerlowski and R. Jain, Physiologically Based Pharmacokinetic Modeling: Principles and Applications, Journal of Pharmaceutical Sciences, vol.72, issue.10, pp.1103-1130, 1983.
DOI : 10.1002/jps.2600721003

X. Wang, M. Santostefano, M. Devito, and L. Birnbaum, Extrapolation of a PBPK Model for Dioxins across Dosage Regimen, Gender, Strain, and Species, Toxicological Sciences, vol.56, issue.1, pp.49-60, 2000.
DOI : 10.1093/toxsci/56.1.49

P. Bernillon and F. Bois, Statistical Issues in Toxicokinetic Modeling: A Bayesian Perspective, Environmental Health Perspectives, vol.108, issue.s5, pp.883-93, 2000.
DOI : 10.1289/ehp.00108s5883

URL : https://hal.archives-ouvertes.fr/ineris-00961852

R. Iman and J. Helton, An Investigation of Uncertainty and Sensitivity Analysis Techniques for Computer Models, Risk Analysis, vol.83, issue.2, pp.71-90, 1988.
DOI : 10.1063/1.445400

R. Spear and F. Bois, Parameter variability and the interpretation of physiologically based pharmacokinetic modeling results, Environmental Health Perspectives, vol.102, issue.Suppl 11, pp.61-67, 1994.
DOI : 10.1289/ehp.94102s1161

F. Bois and D. Maszle, MCSim: a simulation program, Journal of Statistical Software, vol.2, issue.9, 1997.

A. Bernard, C. Hermans, F. Broeckaert, G. De-poorter, A. De-cock et al., Food contamination by PCBs an dioxins, Nature, vol.401, issue.6750, pp.231-233, 1999.
DOI : 10.1038/45717

F. Bois, Applications of population approaches in toxicology, Toxicology Letters, vol.120, issue.1-3, pp.385-94, 2001.
DOI : 10.1016/S0378-4274(01)00270-3

URL : https://hal.archives-ouvertes.fr/ineris-00972203

A. Bernard, F. Broeckaert, D. Poorter, and G. , The Belgian PCB/Dioxin Incident: Analysis of the Food Chain Contamination and Health Risk Evaluation, Environmental Research, vol.88, issue.1, pp.1-18, 2002.
DOI : 10.1006/enrs.2001.4274

W. Parzefall, Risk assessment of dioxin contamination in human food, Food and Chemical Toxicology, vol.40, issue.8, pp.1185-1194, 2002.
DOI : 10.1016/S0278-6915(02)00059-5

N. Davis and W. Mapleson, STRUCTURE AND QUANTIFICATION OF A PHYSIOLOGICAL MODEL OF THE DISTRIBUTION OF INJECTED AGENTS AND INHALED ANAESTHETICS, BJA: British Journal of Anaesthesia, vol.53, issue.4, pp.399-405, 1981.
DOI : 10.1093/bja/53.4.399

D. Staats, J. Fisher, and R. Connoly, Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models, Drug Metabolism and Disposition, vol.19, pp.144-152, 1991.

R. Corley, D. Markham, C. Banks, P. Delorme, A. Masterman et al., Physiologically Based Pharmacokinetics and the Dermal Absorption of 2-Butoxyethanol Vapor by Humans, Fundamental and Applied Toxicology, vol.39, issue.2, pp.120-150, 1997.
DOI : 10.1006/faat.1997.2363

F. Bois, M. Smith, and R. Spear, Mechanisms of benzene carcinogenesis: Application of a physiological model of benzene pharmacokinetics and metabolism, Toxicology Letters, vol.56, issue.3, pp.283-98, 1991.
DOI : 10.1016/0378-4274(91)90157-2

A. Gelman and D. Rubin, Markov chain Monte Carlo methods in biostatistics, Statistical Methods in Medical Research, vol.80, issue.4, pp.339-55, 1996.
DOI : 10.1177/096228029600500402

A. Gelman, F. Bois, and J. Jiang, Physiological Pharmacokinetic Analysis Using Population Modeling and Informative Prior Distributions, Journal of the American Statistical Association, vol.55, issue.436, pp.1400-1412, 1996.
DOI : 10.2307/2533402