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Mécanisme de la toxicité de l'éthylène glycol méthyl éther (EGME) et des isomères du propylène glycol méthyl éther (PGME) sur la reproduction et le développement

Abstract : Glycol ethers are amphiphilic solvents widely used in industrial and domestic applications. Their toxicological effects on mammal reproduction and development have been widely studied, and advises or even prohibitions concerning their used have been published. This family of products shows large structural differences leading to different patterns of metabolism and toxicity. We review here the disruption effects of two glycol ethers of different generations on reproduction and development: ethylene glycol monomethyl ether (EGME), part of the older ethylenic series of glycol ethers, and propylene glycol monomethyl ether (PGME), part of the newer propylenic series. While spermatogenesis alteration and teratogenic effects of EGME are well established, the effects of PGME ask for complementary studies, particularly on the differences between alpha and beta isomers.
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  • HAL Id : ineris-00961880, version 1
  • INERIS : PU-2003-073

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Emmanuel Lemazurier, Luc Multigner, Anthony Lecomte, Franck Robidel, Frédéric Y. Bois. Mécanisme de la toxicité de l'éthylène glycol méthyl éther (EGME) et des isomères du propylène glycol méthyl éther (PGME) sur la reproduction et le développement. Environnement, Risques and Santé, John Libbey Eurotext, 2003, 2 (2), pp.89-96. ⟨ineris-00961880⟩

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