Application des modèles physiologiques à l'analyse de données de toxicocinétique

Abstract : Toxicological studies aim at protecting human populations by quantifying the damages caused by exposure to chemical agents. The main objective of toxicokinetic studies is to describe the relationships between exposure and the effective quantity of toxic reaching tissues of the body. In that context, mathematical models are used to understand physiological phenomena of transport, transformation and elimination of chemicals in the body. For ethical reasons, data allowing to estimate model parameters are poor, sparse, and do not often concern human populations. Recourse to extrapolation is then needed and physiological toxicokinetic models facilitate the required extrapolations (inter-species, inter-subject, ...). The problem induced by the poor quality of data can be partly circumvented in a Bayesian framework where the available a priori values on physiological parameters (blood flows, organ volumes, etc.) can be used.
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  • INERIS : PU-2005-080

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Sandrine Micallef, Frédéric Y. Bois. Application des modèles physiologiques à l'analyse de données de toxicocinétique. Journal de la Société Française de Statistique, Société Française de Statistique et Société Mathématique de France, 2004, 145 (3), pp.15-32. ⟨ineris-00961893⟩

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