Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

L'analyse statistique bayésienne de données toxicocinétiques

Abstract : Bayesian statistical analysis of toxicokinetic data Risk assessment of chemicals requires toxicokinetic studies to determine the association between exposure and the quantity of toxin that reaches target tissues or cells. To characterize this link, experimental data about the agent's spatiotemporal distribution in the body (e.g., blood concentrations at various times) can be collected and analyzed with parametric models (called toxicokinetic or TK models). These models are generally compartmental and can be based on physiology (PBTK models). Appropriate statistical treatment allows fitting TK/PBTK models to the data. Bayesian analysis takes into account and estimates the uncertainty and variability inherent in TK data. It can integrate prior information on parameter values into the estimation process, thus limiting the need for experimental exposures. In this paper, we detail the Bayesian process of TK analysis, including the estimation (or calibration) of parameters and the checking and validation of models. The process can be completed by choosing between competing models or optimizing the design of experimental protocols. To illustrate this process, we analyze and model the toxicokinetics of 1,3-butadiene, a potential human carcinogen.
Document type :
Journal articles
Complete list of metadata

Cited literature [16 references]  Display  Hide  Download
Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Thursday, March 20, 2014 - 3:27:21 PM
Last modification on : Thursday, March 10, 2022 - 2:02:05 PM
Long-term archiving on: : Friday, June 20, 2014 - 12:21:07 PM


Files produced by the author(s)


  • HAL Id : ineris-00961895, version 1
  • INERIS : PU-2005-009



Sandrine Micallef, Céline Brochot, Frédéric y. Bois. L'analyse statistique bayésienne de données toxicocinétiques. Environnement, Risques and Santé, John Libbey Eurotext, 2005, 4 (1), pp.21-34. ⟨ineris-00961895⟩



Record views


Files downloads