Skip to Main content Skip to Navigation
New interface
Journal articles

Influence of aluminium treatments on pulmonary retention of quartz in sheep silicosis

Abstract : Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a more effective alveolar clearance of quartz treated with Al-lac. The present study was undertaken to fully document the effect of Al-lac treatments on the pulmonary retention of quartz. Sheep (on average, 27 per group) received a single injection in the tracheal lobe of either 100 mg/100 mL of alpha-quartz, 100 mg/100 mL of alpha-quartz followed by Al-lac inhalations at 1-month intervals, or 100 mg/100 mL of alpha-quartz Al-lac pretreated in vitro. Samples of lung parenchyma were analyzed at 2, 6, and 10 months after the injection. The quartz concentration in each sample was measured using the X-ray diffraction method. The concentrations were expressed in micrograms of quartz per milligram of dry lung parenchyma. The geometric mean concentrations in each of the three groups at 2 months were statistically different (ANOVA of the log values; p = .016) as well as at 6 months (ANOVA of the log values; p = .001). Al-lac clearly reduced the pulmonary retention of quartz. Both modalities of Al delivery were equally effective in clearing quartz up to 2 months, which may explain the documented reduction in pathological activities after in both forms of therapy. However, quartz soaked in Al-Lac solution was more effective than inhalation of Al-lac after quartz exposure. The half-life of both native quartz and quartz Al-lactate inhaled was 5.05 and 4.99 months, respectively, while it was 3.1 months for Al-treated quartz. Al-lac inhalations after the second month of exposure do not significantly affect the rate of clearance of deposited quartz.
Document type :
Journal articles
Complete list of metadata

https://hal-ineris.archives-ouvertes.fr/ineris-00962578
Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Friday, March 21, 2014 - 1:26:50 PM
Last modification on : Friday, March 21, 2014 - 1:26:50 PM

Identifiers

Collections

Citation

A. Dufresne, Patrick Sebastien, D. Michaud, G. Perrault, R. Begin. Influence of aluminium treatments on pulmonary retention of quartz in sheep silicosis. Experimental Lung Research, 1994, 20 (2), pp.157-168. ⟨10.3109/01902149409064380⟩. ⟨ineris-00962578⟩

Share

Metrics

Record views

33