Biopersistence of Cerium in the Human Respiratory Tract and Ultrastructural Findings - Archive ouverte HAL Access content directly
Journal Articles American Journal of Industrial Medicine Year : 1995

Biopersistence of Cerium in the Human Respiratory Tract and Ultrastructural Findings

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1
Jean-Claude Pairon
  • Function : Author
F. Roos
  • Function : Author
B. Chamak
  • Function : Author
Issam Abd-Alsamad
  • Function : Author
J.F. Bernaudin
  • Function : Author
J. Bignon
  • Function : Author
Patrick Brochard
  • Function : Author

Abstract

For diagnostic purposes, mineralogical analysis was performed in bronchoalveolar lavage fluid and lung tissue from a 58-year-old patient previously exposed to asbestos and rare earth dusts. No significant retention of asbestos was demonstrated in lung tissue by light microscopy (asbestos bodies) or transmission electron microscopy analysis (uncoated fibers). Particles containing rare earth (cerium, lanthanum) and phosphorus were identified in alveolar macrophages in bronchoalveolar lavage fluid, and cerium-containing particles accounted for 70% of particles observed in the lung tissue. Ultrastructural analysis of lung tissue revealed the presence of particles containing cerium and phosphorus in interstitial macrophages and elastic fibers. These results suggest that rare earth is metabolized and should be considered as biopersistent in the human respiratory tract, since occupational inquiries revealed that exposure to cerium oxide abrasive powder had ceased at least 15 years earlier
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Dates and versions

ineris-00962630 , version 1 (21-03-2014)

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Jean-Claude Pairon, F. Roos, Patrick Sebastien, B. Chamak, Issam Abd-Alsamad, et al.. Biopersistence of Cerium in the Human Respiratory Tract and Ultrastructural Findings. American Journal of Industrial Medicine, 1995, 27 (3), pp.349-358. ⟨ineris-00962630⟩

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