Slow-stirring method for determining the n-octanol/water partition coefficient (P-ow) for highly hydrophobic chemicals : performance evaluation in a ring test

Abstract : The n-octanol/water partition coefficient (P-ow) is one of the most important parameters employed for estimating a chemical's environmental fate and toxicity. The currently adopted test guidelines for its determination do not allow for reliable determination of log P-ow greater than 5. The slow-stirring experiment, in contrast, has been demonstrated to provide reliable log P-ow data up to log P-ow of 8.3. To validate this method and to obtain its approval as an official Organization for Economic Cooperation and Development (Paris, France) test guideline, a ring test was performed to evaluate the accuracy and precision of the slow-stirring experiment for determination of log P-ow particularly for highly hydrophobic compounds. Up to 15 volunteer laboratories tested 1,2,3,4-tetrachlorobenzene, hexachlorobenzene, 2,2',3,3',5,5',6,6'-octachlorobiphenyl, and decachlorobiphenyl (4.5 < log P-ow < 8.2). The ring-test results for the respective chemicals were 4.62, 5.50, 7.39, and 8.18. The results deviated by less than 0.1 log P-ow units from the reference log P-ow In addition, the relative standard deviations of log P-ow were less than 2 %. Using the protocol of the ring test, log P-ow of p,p'-DDT was determined to be 6.24 +/- 0.05 (mean +/- standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log P-ow of highly hydrophobic chemicals.
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Submitted on : Friday, March 21, 2014 - 1:59:20 PM
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J. Tolls, K. Bodo, E. de Felip, Roland Dujardin, Y.H. Kim, et al.. Slow-stirring method for determining the n-octanol/water partition coefficient (P-ow) for highly hydrophobic chemicals : performance evaluation in a ring test. Environmental Toxicology and Chemistry, Wiley, 2003, 22 (5), pp.1051-1057. ⟨10.1002/etc.5620220512⟩. ⟨ineris-00962855⟩

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