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Acute exposure to GSM 900-MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain

Abstract : The worldwide proliferation of mobile phones raises the question of the effects of 900-MHz electromagnetic fields (EMF) on the brain. Using a head-only exposure device in the rat, we showed that a 15-min exposure to 900-MHz pulsed microwaves at a high brain-averaged power of 6 W/kg induced a strong glial reaction in the brain. This effect, which suggests neuronal damage, was particularly pronounced in the striatum. Moreover, we observed significant and immediate effects on the K-d and B-max values of N-methyl-D-aspartate (NMDA) and GABA(A) receptors as well as on dopamine transporters. Decrease of the amount of NMDA receptors at the postsynaptic membrane is also reported. Although we showed that the rat general locomotor behavior was not significantly altered on the short term, our results provide the first evidence for rapid cellular and molecular alterations in the rat brain after an acute exposure to high power GSM (Global System for Mobile communication) 900-MHz microwaves.
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https://hal-ineris.archives-ouvertes.fr/ineris-00962918
Contributor : Gestionnaire Civs <>
Submitted on : Friday, March 21, 2014 - 1:59:53 PM
Last modification on : Thursday, November 19, 2020 - 4:40:13 PM

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Anne-Laure Mausset-Bonnefont, Hélène Hirbec, X. Bonnefont, Alain Privat, J. Vignon, et al.. Acute exposure to GSM 900-MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain. Neurobiology of Disease, Elsevier, 2004, 17 (3), pp.445-454. ⟨10.1016/j.nbd.2004.07.004⟩. ⟨ineris-00962918⟩

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