Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotoptc compositions of uranium

Sabrina Barillet 1 Christelle Adam 1 Olivier Palluel 2 Alain Devaux 3, 4
1 Institut de Radioprotection et de Sûreté Nucléaire
2 INERIS - Institut National de l'Environnement Industriel et des Risques
3 Laboratoire des Sciences de l'Environnement
4 DEPT EFPA - Département Ecologie des Forêts, Prairies et milieux Aquatiques
Abstract : Experiments were carried out on adult male zebrafish (Danio rerio) to assess early changes induced by waterborne exposure to different isotopic compositions of uranium (depleted uranium associated or not with U-233). Oxidative stress and neurotoxicity were selected as effect endpoints to characterize uranium chemo- and radiotoxicity. Catalase, glutathione peroxidase, and superoxide dismutase activities and total glutathione content of hepatic extracts, as well as brain acetylcholinesterase activity and uranium bioaccumulation, were measured. Oxidative stress induced by uranium exposure led to decreases in superoxide dismutase and catalase activity levels as well as total glutathione content in liver extracts. These perturbations were significantly more marked in U-233-exposed fish. Furthermore, significant increase in acetylcholinesterase activity was observed in brain extracts at the same level, whatever the isotopic composition of uranium.
keyword : DANIO RERIO URANIUM BIOACCUMULATION OXIDATIVE STRESS NEUROTOXICITY
Document type :
Journal articles
Complete list of metadatas
https://hal-ineris.archives-ouvertes.fr/ineris-00963069
Contributor : Gestionnaire Civs <>
Submitted on : Friday, March 21, 2014 - 2:11:54 PM
Last modification on : Wednesday, November 29, 2017 - 9:50:33 AM

Links full text

istex

Identifiers

Collections

INERIS | ENTPE | INRA | IRSN

Citation

Sabrina Barillet, Christelle Adam, Olivier Palluel, Alain Devaux. Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotoptc compositions of uranium. Environmental Toxicology and Chemistry, Wiley, 2007, 26 (3), pp.497-505. ⟨10.1897/06-243R.1⟩. ⟨ineris-00963069⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

168

Contact

CCSD