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Effect of an acute 900 MHz GSM exposure on glia in the rat brain : A time-dependent study

Abstract : Because of the increasing use of mobile phones, the possible risks of radio frequency electromagnetic fields adverse effects on the human brain has to be evaluated. In this work we measured GEAP expression, to evaluate glial evolution 2, 3, 6 and 10 days after a single GSM exposure (15 min, brain averaged SAR = 6W/kg, 900MHz signal) in the rat brain. A statistically significant increase of GEAP stained surface area was observed 2 days after exposure in the frontal cortex and the caudate putamen. A smaller statistically significant increase was noted 3 days after exposure in the same areas and in the cerebellum cortex. Our results confirm the Mausset-Bonnefont et al. study [Mausset-Bonnefont, A.L., Hirbec, H., Bonnefont, X., Privat, A., Vignon, J., de Seze, R., 2004. Acute exposure to GSM 900 MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain. Neurobiol. Dis. 17, 445-454], showing the existence of glial reactivity after a 15 min GSM acute exposure at a brain averaged SAR of 6 W/kg. We conclude to a temporary effect, probably due to a hypertrophy of glial cells, with a temporal and a spatial modulation of the effect. Whether this effect could be harmful remains to be studied.
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Submitted on : Friday, March 21, 2014 - 2:12:10 PM
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Elsa Brillaud, Aleksandra Piotrowski, René de Seze. Effect of an acute 900 MHz GSM exposure on glia in the rat brain : A time-dependent study. Toxicology, Elsevier, 2007, 238 (1), pp.23-33. ⟨10.1016/j.tox.2007.05.019⟩. ⟨ineris-00963085⟩

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