Biodistribution and clearance of instilled carbon nanotubes in rat lung - Archive ouverte HAL Access content directly
Journal Articles Particle and Fibre Toxicology Year : 2008

Biodistribution and clearance of instilled carbon nanotubes in rat lung

(1) , (2) , (1) , (1) , (1) , (1) , (1) , (3, 4) , (1)
1
2
3
4

Abstract

Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration

Dates and versions

ineris-00963147 , version 1 (21-03-2014)

Identifiers

Cite

Dan Elgrabli, Magali Floriani, Steve Abella-Gallart, Laurent Meunier, Christelle Gamez, et al.. Biodistribution and clearance of instilled carbon nanotubes in rat lung. Particle and Fibre Toxicology, 2008, 5 (20), pp.NC. ⟨10.1186/1743-8977-5-20⟩. ⟨ineris-00963147⟩
95 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More