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Biodistribution and clearance of instilled carbon nanotubes in rat lung

Abstract : Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration
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https://hal-ineris.archives-ouvertes.fr/ineris-00963147
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Submitted on : Friday, March 21, 2014 - 2:17:34 PM
Last modification on : Saturday, March 28, 2020 - 2:21:54 AM

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Dan Elgrabli, Magali Floriani, Steve Abella-Gallart, Laurent Meunier, Christelle Gamez, et al.. Biodistribution and clearance of instilled carbon nanotubes in rat lung. Particle and Fibre Toxicology, BioMed Central, 2008, 5 (20), pp.NC. ⟨10.1186/1743-8977-5-20⟩. ⟨ineris-00963147⟩

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