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Effect of (xeno)-estrogens on zebrafish P450c17 (C17, 17 alpha-hydroxylase/17, 20-lyase) mRNA and protein expression in gonadal tissue

François Brion 1 Nathalie Hinfray 1 Olivier Palluel 1 Julien Maillard 1 Isabelle Anglade 2 Selim Ait-Aissa 1 Olivier Kah 2 Jean-Marc Porcher 1
1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 Interactions Cellulaires et Moléculaires
Abstract : The objectives of this study were to determine the expression and the cellular localization of P450c17 in gonadal tissues in the zebrafish and to investigate the effect of (xeno)-hormones on its expression at both mRNA and protein levels. We showed that gonads are sites for cyp17 gene expression and we documented for the first time the cellular localization of the cyp17 protein expression within ovarian and testicular tissues in a cyprinid fish. Moreover, we demonstrated the down-regulating effect of (xeno)-estrogens on testicular cyp17 expression.
Mots-clés : STEROIDOGENESE P450C17 GENE PROTEINE EXPRESSSION GONADES POISSON ZEBRE
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STEROIDOGENESIS GENE EXPRESSION GONADS ZEBRAFISH
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https://hal-ineris.archives-ouvertes.fr/ineris-00963150
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Submitted on : Friday, March 21, 2014 - 2:17:35 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:33 AM

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  • HAL Id : ineris-00963150, version 1
  • INERIS : EN-2008-067

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INERIS | CNRS | UNIV-RENNES1 | IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

Citation

François Brion, Nathalie Hinfray, Olivier Palluel, Julien Maillard, Isabelle Anglade, et al.. Effect of (xeno)-estrogens on zebrafish P450c17 (C17, 17 alpha-hydroxylase/17, 20-lyase) mRNA and protein expression in gonadal tissue. Cybium : Revue Internationale d’Ichtyologie, Paris : Muséum national d'histoire naturelle, 2008, 32 (2, suppl. S), pp.245-246. ⟨ineris-00963150⟩

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