GFAP expression in the rat brain following sub-chronic exposure to a 900 MHz electromagnetic field signal

Mohamed Ammari 1 Christelle Gamez 1 Anthony Lecomte 1 Mohsen Sakly 2 Hafedh Abdelmelek 2 René de Seze 1
1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 Laboratoire de Physiologie Intégrée
Abstract : Methods: Sprague-Dawley rats were exposed for 45 min/day at a brain-averaged specific absorption rate (SAR) = 1.5 W/kg or 15 min/day at a SAR = 6 W/kg for five days per week during an eight-week period. GFAP expression was measured by the immunocytochemistry method in the following rat brain areas: Prefrontal cortex, cerebellar cortex, dentate gyrus of the hippocampus, lateral globus pallidus of the striatum, and the caudate putamen. Results: Compared to the sham-treated rats, those exposed to the sub-chronic GSM (Global System for mobile communications) signal at 1.5 or 6 W/kg showed an increase in GFAP levels in the different brain areas, three and ten days after treatment. Conclusion: Our results show that sub-chronic exposures to a 900 MHz EMF signal for two months could adversely affect rat brain (sign of a potential gliosis).
Keywords : ASTROCYTE GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) ELECTROMAGNETIC FIELD RAT BRAIN
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Journal articles
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Submitted on : Friday, March 21, 2014 - 2:18:36 PM
Last modification on : Friday, March 21, 2014 - 2:18:36 PM

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Mohamed Ammari, Christelle Gamez, Anthony Lecomte, Mohsen Sakly, Hafedh Abdelmelek, et al.. GFAP expression in the rat brain following sub-chronic exposure to a 900 MHz electromagnetic field signal. International Journal of Radiation Biology, Informa Healthcare, 2010, 86 (5), pp.367-375. ⟨10.3109/09553000903567946⟩. ⟨ineris-00963219⟩

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