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In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques

Achraf Al Faraj 1 F. Fauvelle 2 N. Luciani 3 Ghislaine Lacroix 4 Yannick Cremillieux 1 Emmanuelle Canet-Soulas 1
1 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2 Biophysique Cellulaire et Moléculaire
3 MSC (UMR_7057) - Matière et Systèmes Complexes
4 INERIS - Institut National de l'Environnement Industriel et des Risques
Abstract : Single-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered in vivo, their biodistribution and pharmacological profile needs to be fully characterized. The tissue distribution of carbon nanotubes and their potential impact on metabolism depend on their shape, coating, and metallic impurities. Because standard radiolabeled or fluorescentlylabeled pharmaceuticals are not well suited for long-term in vivo follow-up of carbon nanotubes, alternative methods are required.
Keywords : SINGLE-WALLED CARBON NANOTUBES MAGNETIC RESONANCE IMAGING HIGH RESOLUTION MAGIC ANGLE SPINNING
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Submitted on : Friday, March 21, 2014 - 2:22:30 PM
Last modification on : Thursday, March 4, 2021 - 5:54:20 PM

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INERIS | CNRS | UNIV-PARIS7 | CREATIS | HCL | USPC | UNIV-LYON1 | UNIV-ST-ETIENNE | INSA-GROUPE | UDL | UNIV-PARIS | UP-SCIENCES

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Achraf Al Faraj, F. Fauvelle, N. Luciani, Ghislaine Lacroix, Yannick Cremillieux, et al.. In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques. International Journal of Nanomedicine, Dove Medical Press, 2011, 6, pp.351-361. ⟨10.2147/IJN.S16653⟩. ⟨ineris-00963286⟩

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