In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant. - Archive ouverte HAL Access content directly
Journal Articles Environmental Science and Technology Year : 2011

In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant.

(1) , , (2) , , , , (3) , (4) , (4) , , (5)
1
2
3
4
5

Abstract

Epidemiological studies in urban areas have linked increasing respiratory and cardiovascular pathologies with atmospheric particulate matter (PM) from anthropic activities. However, the biological fate of metal-rich PM industrial emissions in urban areas of developed countries remains understudied. Lead toxicity and bioaccessibility assessments were therefore performed on emissions from a lead recycling plant, using complementary chemical acellular tests and toxicological assays, as a function of PM size (PM10–2.5, PM2.5–1 and PM1) and origin (furnace, refining and channeled emissions). Process PM displayed differences in metal content, granulometry, and percentage of inhalable fraction as a function of their origin. Lead gastric bioaccessibility was relatively low (maximum 25%) versus previous studies; although, because of high total lead concentrations, significant metal quantities were solubilized in simulated gastrointestinal fluids. Regardless of origin, the finest PM1 particles induced the most significant pro-inflammatory response in human bronchial epithelial cells. Moreover, this biological response correlated with pro-oxidant potential assay results, suggesting some biological predictive value for acellular tests. Pulmonary effects from lead-rich PM could be driven by thiol complexation with either lead ions or directly on the particulate surface. Finally, health concern of PM was discussed on the basis of pro-inflammatory effects, accellular test results, and PM size distribution
Fichier principal
Vignette du fichier
Uzu_5519.PDF (921.62 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

ineris-00963305 , version 1 (09-12-2021)

Identifiers

Cite

Gaëlle Uzu, Jean-Jacques Sauvain, Armelle Baeza-Squiban, Michael Riediker, Magdalena Sanchez, et al.. In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant.. Environmental Science and Technology, 2011, 45 (18), pp.7888-7895. ⟨10.1021/es200374c⟩. ⟨ineris-00963305⟩
324 View
23 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More