Exposure assessment of phthalates in French pregnant women : Results of the ELFE pilot study

Florence Anna Zeman 1 Céline Boudet 1 Karine Tack 1 Adeline Barneaud 1 Céline Brochot 1 Alexandre Pery 1 Amivi Oleko 2 Stéphanie Vandentorren 2
1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 Institut National de Veille Sanitaire
Abstract : The ubiquitous use of phthalate esters in plastics, building material, medical devices, personal care products and food packaging materials results in a widespread exposure of general population. This study reports measurement of urinary concentration of phthalate metabolites in France and provides a first assessment of the exposure of French pregnant women to this chemical class. For the majority of the phthalate metabolites, concentrations measured in urine were similar to those reported in previous studies except for two phthalates that were characterized by high concentrations of metabolites if compared to previous European and American studies: DiNP (Di-iso-nonylphthalate) and DEHP (Di(2-ethylhexyl)phthalate). In a second part of the study, a pharmacokinetic model was used in order to gain understanding on exposure to DEHP. A high concentration of the primary metabolite of DEHP, MEHP (Mono(2-ethylhexyl)phthalate), was thus identified probably because of a very recent exposure to perfusion materials at the hospital. Pharmacokinetics modelling highlighted that gathering data on the time gap between exposure and biomonitoring is an essential information requirement for reconstructing the dose of non persistent pollutants. Information about exposure pathway is also crucial for conducting effective reverse dosimetry.
Keywords : PHTHALATES DEHP TOXICOKINETICS BIOMONITORING REVERSE DOSIMETRY
Document type :
Journal articles
Complete list of metadatas
https://hal-ineris.archives-ouvertes.fr/ineris-00963467
Contributor : Gestionnaire Civs <>
Submitted on : Friday, March 21, 2014 - 2:32:15 PM
Last modification on : Friday, March 21, 2014 - 2:32:15 PM

Identifiers

Collections

INERIS

Citation

Florence Anna Zeman, Céline Boudet, Karine Tack, Adeline Barneaud, Céline Brochot, et al.. Exposure assessment of phthalates in French pregnant women : Results of the ELFE pilot study. International Journal of Hygiene and Environmental Health, Elsevier, 2013, 216 (3), pp.271-279. ⟨10.1016/j.ijheh.2012.12.005⟩. ⟨ineris-00963467⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

284

Contact

CCSD