Skip to Main content Skip to Navigation
Journal articles

Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential

Abstract : The potential (eco)toxicological hazard posed by engineered nanoparticles is a major scientific and societal concern since several industrial sectors (e.g. electronics, biomedicine, and cosmetics) are exploiting the innovative properties of nanostructures resulting in their large-scale production. Many consumer products contain nanomaterials and, given their complex life-cycle, it is essential to anticipate their (eco)toxicological properties in a fast and inexpensive way in order to mitigate adverse effects on human health and the environment. In this context, the application of the structure-toxicity paradigm to nanomaterials represents a promising approach. Indeed, according to this paradigm, it is possible to predict toxicological effects induced by chemicals on the basis of their structural similarity with chemicals for which toxicological endpoints have been previously measured. These structure-toxicity relationships can be quantitative or qualitative in nature and they can predict toxicological effects directly from the physicochemical properties of the entities (e.g. nanoparticles) of interest. Therefore, this approach can aid in prioritizing resources in toxicological investigations while reducing the ethical and monetary costs that are related to animal testing. The purpose of this review is to provide a summary of recent key advances in the field of QSAR modelling of nanomaterial toxicity, to identify the major gaps in research required to accelerate the use of quantitative structure-activity relationship (QSAR) methods, and to provide a roadmap for future research needed to achieve QSAR models useful for regulatory purposes.
Document type :
Journal articles
Complete list of metadatas

https://hal-ineris.archives-ouvertes.fr/ineris-00963500
Contributor : Gestionnaire Civs <>
Submitted on : Friday, March 21, 2014 - 2:32:40 PM
Last modification on : Thursday, August 29, 2019 - 1:36:18 PM

Identifiers

Collections

Citation

David A. Winkler, Enrico Mombelli, Antonio Pietroiusti, Lang Tran, Andrew P. Worth, et al.. Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential. Toxicology, Elsevier, 2013, 313 (1), pp.15-23. ⟨10.1016/j.tox.2012.11.005⟩. ⟨ineris-00963500⟩

Share

Metrics

Record views

259