Oral bioavailability

Mark Cave 1 Joanna Wragg 1 Sébastien Denys 2 Catherine Jondreville 3 Cyril Feidt 3
1 British Geological Survey [Keyworth]
2 INERIS - Institut National de l'Environnement Industriel et des Risques
3 URAFPA - Unité de Recherches Animal et Fonctionnalités des Produits Animaux
Abstract : Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described and contrasted. The role of the physico-chemical properties of the soils that control the bioavailability of contaminants are summarised. Finally, examples of how bioavailability/bioaccessibility studies of soils from both anthropogenic and geogenic origin are discussed along with the criteria required for deciding whether bioavailability data should be used in a Human Health Risk Assessment.
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Submitted on : Wednesday, April 2, 2014 - 2:06:39 PM
Last modification on : Friday, February 22, 2019 - 3:00:02 PM

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  • HAL Id : ineris-00969439, version 1
  • INERIS : EN-2011-370

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INERIS | UNIV-LORRAINE | INRA | URAFPA-UL

Citation

Mark Cave, Joanna Wragg, Sébastien Denys, Catherine Jondreville, Cyril Feidt. Oral bioavailability. SWARTJES, Frank A. Dealing with contaminated sites. From theory towards practical application, Springer. Dordrecht, pp.287-324, 2011, Earth and Environmental Science. ⟨ineris-00969439⟩

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