Oral bioavailability

Mark Cave (1) , Joanna Wragg (1) , Sébastien Denys (2) , Catherine Jondreville (3) , Cyril Feidt (3)

1 British Geological Survey [Keyworth]
2 INERIS - Institut National de l'Environnement Industriel et des Risques
3 URAFPA - Unité de Recherches Animal et Fonctionnalités des Produits Animaux

Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described and contrasted. The role of the physico-chemical properties of the soils that control the bioavailability of contaminants are summarised. Finally, examples of how bioavailability/bioaccessibility studies of soils from both anthropogenic and geogenic origin are discussed along with the criteria required for deciding whether bioavailability data should be used in a Human Health Risk Assessment.

Domains: Environmental Sciences

Mark Cave, Joanna Wragg, Sébastien Denys, Catherine Jondreville, Cyril Feidt. Oral bioavailability. SWARTJES, Frank A. Dealing with contaminated sites. From theory towards practical application, Springer. Dordrecht, pp.287-324, 2011, Earth and Environmental Science. ⟨ineris-00969439⟩