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Integrated testing strategy (ITS) on acute toxicity in the context of REACH

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Abstract

In Europe, the new regulation for the chemicals safety management named REACh lays down a clear obligation to carry out vertebrate testing only as a last resort. In that context, the RIP 3.3, one of the REACh Implementation project, had to provide a comprehensive guidance on the collection and assessment of the available information on the intrinsic properties of the substances to be registered under REACH, on the requirement specified by the Regulation, on the identification of data gaps and on the generation of the additional information required to comply with the Regulation. One part of the guidance had developed an endpoint specific guidance on meeting the information requirements on physicochemical properties and the different human health and the environmental endpoints and how to address the aspects of gathering, evaluation and generation of information to help registrants provide adequate and relevant information for an adequate registration. Each endpoint specific guidance is presented in 6 sections and the final and probably most important section comprises an Integrated Testing Strategy (ITS) for the given endpoint. The ITS developed on acute toxicity provided guidance on using all available information (QSARs,animal and non-animal data) to be able to purchase classification and labelling and/or risk assessment in a weight of evidence approach.
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ineris-00970274 , version 1 (02-04-2014)

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Sylvie Tissot. Integrated testing strategy (ITS) on acute toxicity in the context of REACH. 6. World Congress on alternatives and animal use in the life sciences, Aug 2007, Tokyo, Japan. ⟨ineris-00970274⟩

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