e-endocrine disrupting chemical databases for deriving QSAR models - Ineris - Institut national de l'environnement industriel et des risques Accéder directement au contenu
Communication Dans Un Congrès Année : 2007

e-endocrine disrupting chemical databases for deriving QSAR models

Résumé

There is increasing evidence that numerous chemicals released into the environment by human activities have the potential to alter the normal functions of the endocrine system in wildlife. These xenobiotics, mimicking natural hormones, are called endocrine disrupting chemicals (EDCs). The aim of this study was to catalogue the different EDC database (biological data, chemical descriptor data, etc.) resources available on the Internet for deriving structure-activity models. In vitro and in vivo experimental data on nuclear receptor binding assays, in vitro test methods reliability and variability assessment for detecting EDCs and comparison between biological assays will be presented and critically analysed.
Fichier non déposé

Dates et versions

ineris-00970315 , version 1 (02-04-2014)

Identifiants

  • HAL Id : ineris-00970315 , version 1
  • INERIS : EN-2007-334

Citer

Nathalie Marchand-Geneste, James Devillers, Jean-Christophe Dore, Jean-Marc Porcher. e-endocrine disrupting chemical databases for deriving QSAR models. 4. International Symposium "Computational Methods in Toxicology and Pharmacology Integrating Internet Resources" (CMTPI 2007), Sep 2007, Moscou, Russia. ⟨ineris-00970315⟩
79 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More