HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Conference papers

Pulmonary responses to silica dust : the influence of crystalline structures and physico-chemical properties

Abstract : The inhalation of silica crystalline polymorphs leads to the development of pulmonary nodules that vary in extent and in fibrotic content. In this study, a single protocol was used to test different silica samples (i.e., 2 non-crystalline samples: one vitreous silica, one diatomaceous earth , 4 crystalline samples: one pure a-quartz ground in a wet atmosphere, one of the same quartz heated until it becomes oc-cristobalite and 2 cristobalites obtained by heating diatomaceous earth). Wistar rats received a single intra-tracheal injection of alveolar dust and were followed over a period of 3 months. The results were exploited using macroscopic examination (wet lung weight), histological examination and biochemical dosing (hydroxyproline, lipid, and silica content). The results showed that vitreous silica, diatomaceous earth, wet-ground quartz and both types of cristobalites are responsible to a greater or lesser extent for the pulmonary reaction typical of exposure to silica (i.e., nodules ); with different cellular and fibrotic surface areas for each sample. a-cristobalite (obtained from the wet-ground quartz heated to a very high temperature; 1,300 °C) leads to the formation of only small foreign-body granulomas. All crystalline minerals tested caused alveolar lipoproteinosis. It was thus concluded that the crystalline structure plays a less important role than the surface state in the formation of silicotic nodules.
Document type :
Conference papers
Complete list of metadata

Cited literature [12 references]  Display  Hide  Download

Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Thursday, April 3, 2014 - 1:32:11 PM
Last modification on : Friday, November 8, 2019 - 3:00:02 PM
Long-term archiving on: : Thursday, July 3, 2014 - 1:05:50 PM


Files produced by the author(s)


  • HAL Id : ineris-00971883, version 1
  • INERIS : PU-1993-078



Sylvie Honnons, Dominique Oberson, Agnès Wastiaux, S. Dzwigaj, H. Pezerat, et al.. Pulmonary responses to silica dust : the influence of crystalline structures and physico-chemical properties. 2. International Symposium on Silica Silicosis & Cancer, Oct 1993, San Francisco, United States. ⟨ineris-00971883⟩



Record views


Files downloads