Research on an effect of a short term exposure to low concentrations of ozone on V79 cells using the comet assay

Pascale Debersac (1) , Michèle Bisson (1) , A. Malo (1) , F. Petitot (2) , Jean-Marc Porcher (1) , Claude Lambre (1)

1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 CEA/DSV

During episode of atmospheric pollution in industrialized areas, the ozone concentration can reach up to 0.35 ppm for a few hours. These concentrations are beyond the protection thresholds for human health and vegetation recommended by EU directive 92/72 and based on the guidelines of the World Health Organisation. Ozone is not by itself a radicalar species, but most of its toxic effects are thought to result from radicalar reactions mediated by .OH or by nucleases activation. So far, most of the genotoxic effects reported have been observed in vitro at concentrations in the range of 1 to 10 ppm during 1 hour (Victorin, 1992), that is higher than the actual individual exposure.

Domaines: Sciences de l'environnement

Pascale Debersac, Michèle Bisson, A. Malo, F. Petitot, Jean-Marc Porcher, et al.. Research on an effect of a short term exposure to low concentrations of ozone on V79 cells using the comet assay. 7. International Inhalation Symposium "Relationships between Acute and Chronic Effects of Air Pollution", Feb 1999, Hanovre, Germany. ⟨ineris-00972159⟩