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Toxicité des nanoparticules : cas des nanotubes de carbone

Abstract : Constituted only by carbon atoms, carbon nanotubes (CNT) are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. In this work, we propose to study the effect of bovine serum albumin as a dispersing agent for CNT. The toxicological effect of a multi walled CNT (MWCNT) and a method to investigate the biopersistance of CNT in organism, based on detection of nickel, a metallic impurity present in the MWCNT we investigated were then analyses. Our results, in rats that received 100 micro g of MWCNT by a unique intratracheal instillation, reveal that MWCNT do not induce histopathological lesions, modifications of physiological pulmonary parameters and inflammation. Moreover, MWCNT do not significantly cross the pulmonary barrier and can be eliminated by a slow mechanism. Using electonic microscopy and infrared spectroscopy, we showed that MWCNT may be cleaved and chemically modified in the lung. Analyses of MWCNT lung clearance mechanism lead us to propose a hypothesis based on the phagocytosis, apoptosis of alveolar macrophages, possible degradation of MWCNT by alveolar macrophages, and elimination of apoptotic cells.
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  • HAL Id : ineris-00973334, version 1
  • INERIS : EN-2009-061



Dan Elgrabli, Ghislaine Lacroix. Toxicité des nanoparticules : cas des nanotubes de carbone. 8. Congrès International pluridisciplinaire QUALITA 2009, Mar 2009, Besançon, France. pp.NC. ⟨ineris-00973334⟩



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