Effects of cell phone radiofrequency exposure on the human cytochrome P450 reductase

Effets de l'exposition aux radiofréquences de téléphone portable sur le cytochrome P450 réductase humain

Shazia Tanvir (1) , György Thuróczy (2) , Brahim Selmaoui (2) , Viviane Silva Pires-Antonietti (3) , Pascal Sonnet (3) , Philippe Lévêque (4) , René de Seze (2) , Sylviane Pulvin (1)

1 GEC - Génie Enzymatique et Cellulaire
2 INERIS - Institut National de l'Environnement Industriel et des Risques
3 LG - Laboratoire des Glucides
4 XLIM-OSA - OSA

Accelerated and widespread of cell phones has increased the human exposure to radiofrequency electromagnetic fields (EMFs) and raises serious concerns about the biological and health-related effects of RF radiation. The present study aimed at the effect of cell phone RF (1.9 GHz) emitted by Universal Mobile Telecommunication System (UMTS), the third generation (3G) of cell phones on structure and function of human cytochrome P450 reductase. The ability of the cytochrome P450 reducatese to transfer the electron was measured by an exogenous electron acceptor cytochrome C with UV-vis spectrophotometer. Structural changes were studied by fluorescence spectroscopy, dynamic light scattering, Circular dichroism and capillary electrophoresis (Zeta potential). The results indicated that UMTS-like onehour RF exposure at 1 W/kg SAR slightly altered electron transfer ability and structure of cytochrome P450 reductases.

Keywords: RADIOFREQUENCE (RF); TELEPHONE PORTABLE; UMTS; CYTOCHROME P450 REDUCTASE<br />---<br />CELL PHONE RADIATION; RADIOFREQUENCY (RF); CYTOCHROME P450 REDUCTASE

Domains: Toxicology; Environmental Sciences

Shazia Tanvir, György Thuróczy, Brahim Selmaoui, Viviane Silva Pires-Antonietti, Pascal Sonnet, et al.. Effects of cell phone radiofrequency exposure on the human cytochrome P450 reductase. Journées Scientifiques URSI-France JS'12 "Champs électromagnétiques : de la dosimétrie à la santé humaine", Apr 2012, Paris, France. pp.225-227. ⟨ineris-00973656⟩