Genotoxic effects of ultraviolet (UV) radiation on human 3D skin model in vitro

Zsuzsanna Nemeth , Gyorgyi Kubinyi , Annamaria Brech , Erzsebet Szaladjak , Jozsef Bakos , Zsolt Forgacs , Brahim Selmaoui (1, 2) , György Thuróczy

1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1

The aim of this experiment was to examine whether the UVA or UVB exposure with two doses each has genotoxic effect on human reconstructed skin in vitro. The DNA damage was detected by comet assay. In this preliminary study we managed to show the direct damaging effect of the UVB radiation on the DNA, but UVA exposure did not have any significant effect. This experiment was done as a preliminary study for the project named “Cellular response to co-exposure of radiofrequency (RF) and solar ultraviolet (UV) radiation in human in vitro skin model (SKIN-RF)”.

Domains: Toxicology

Zsuzsanna Nemeth, Gyorgyi Kubinyi, Annamaria Brech, Erzsebet Szaladjak, Jozsef Bakos, et al.. Genotoxic effects of ultraviolet (UV) radiation on human 3D skin model in vitro. Annual meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association (BioEM 2016), Jun 2016, Ghent, Belgium. ⟨ineris-01853039⟩