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Journal Articles Toxicological Sciences Year : 2017

FutureTox III : Bridges for translation

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Daland R. Juberg
  • Function : Author
Thomas B. Knudsen
  • Function : Author
Miriam Sander
  • Function : Author
Nancy B. Beck
  • Function : Author
Elaine Faustman
  • Function : Author
Donna Mendrick
  • Function : Author
John R. Fowle
  • Function : Author
Thomas Hartung
  • Function : Author
Raymond R. Tice
  • Function : Author
Richard A. Becker
  • Function : Author
Suzanne Compton Fitzpatrick
  • Function : Author
George P. Daston
  • Function : Author
Alison Harrill
  • Function : Author
Ronald N. Hines
  • Function : Author
Douglas A. Keller
  • Function : Author
John C. Lipscomb
  • Function : Author
David Watson
  • Function : Author
Tina Bahadori
  • Function : Author
Kevin Crofton
  • Function : Author

Abstract

Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question—what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making.

Dates and versions

ineris-01853424 , version 1 (03-08-2018)

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Daland R. Juberg, Thomas B. Knudsen, Miriam Sander, Nancy B. Beck, Elaine Faustman, et al.. FutureTox III : Bridges for translation. Toxicological Sciences, 2017, 155 (1), pp.22-31. ⟨10.1093/toxsci/kfw194⟩. ⟨ineris-01853424⟩

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