Integrated modeling of endocrine disruption in zebrafish at different biological levels (MOZAIC)

Abstract : The translation of subtle functional deficits within individuals into population-level effects is identified as a main challenge for the hazard and risk assessment of endocrine disruptor compounds (EDCs) in fish. Among model species for ecotoxicological investigations, zebrafish (Danio reiro) is a vertebrate organism extensively used for scientific purposes and an increasing amount of toxicological data of EDCs toward zebrafish have been gathered during the past years. Thus, the aim of MOZAIC project was to propose an integrated modelling framework for zebrafish to assess how EDCs modify the level of hormones in individuals and how such disruption will impact individual fitness and population dynamics.