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Results of a round-robin exercise on read-across

Emilio Benfenati 1 Maria Belli 1 T. Borges E. Casimiro Josep Cester Alberto Fernandez G. Gini M. Honma M. Kinzl R. Knauf A. Manganaro Enrico Mombelli 2 M.I. Petoumenou 1 M. Paparella P. Paris 3 Giuseppa Raitano 1
1 IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico
2 INERIS - Institut National de l'Environnement Industriel et des Risques
3 ISPRA - Istituto Superiore per la Protezione e la Ricerca Ambientale
Abstract : A round-robin exercise was conducted within the CALEIDOS LIFE project. The participants were invited to assess the hazard posed by a substance, applying in silico methods and read-across approaches. The exercise was based on three endpoints: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were assigned for each endpoint and the participants were invited to complete a specific questionnaire communicating their conclusions. The interesting aspect of this exercise is the justification behind the answers more than the final prediction in itself. Which tools were used? How did the approach selected affect the final answer ?
Keywords : READ-ACROSS MUTAGENICITY BIOCONCENTRATION FACTOR
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https://hal-ineris.archives-ouvertes.fr/ineris-01854129
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Submitted on : Monday, August 6, 2018 - 2:54:49 PM
Last modification on : Thursday, August 29, 2019 - 10:10:02 AM

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Emilio Benfenati, Maria Belli, T. Borges, E. Casimiro, Josep Cester, et al.. Results of a round-robin exercise on read-across. SAR and QSAR in Environmental Research, Taylor & Francis, 2016, 27 (5), pp.371-384. ⟨10.1080/1062936X.2016.1178171⟩. ⟨ineris-01854129⟩

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