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Assessing the impact of a single biomarker measurement to reconstruct the exposure of pregnant women to Di(2-ethylhexyl) phthalate

Abstract : Large-scale human biomonitoring surveys typically gather biomarker measurements from single time points. For non-persistent compounds (i.e., with a biological half-life of hours), the biomarker levels are known to greatly vary within the same individual over a relatively short time period. In this work, we aimed at assessing the impact of a single biomarker measurement to reconstruct the exposure of individuals to a non-persistent compound (a phthalate) by testing several sampling scenarios. In particular, we studied the exposure of pregnant women to Di(2-ethylhexyl) phthalate (DEHP) using the urinary concentrations of four DEHP metabolites. Phthalates are a family of chemicals that can be found in a wide array of products, and are suspected to induce reproductive and developmental toxicity.
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Submitted on : Tuesday, August 7, 2018 - 9:16:26 AM
Last modification on : Tuesday, August 7, 2018 - 9:16:27 AM

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Doris Tan, Florence Anna Zeman, Maribel Casas, Amrit K. Sakhi, Berit Granum, et al.. Assessing the impact of a single biomarker measurement to reconstruct the exposure of pregnant women to Di(2-ethylhexyl) phthalate. ISES 2016 Annual Meeting, Oct 2016, Utrecht, Netherlands. pp.370. ⟨ineris-01854694⟩

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