Development of a generic PBPK model for pyrethroids to assess the cumulative exposure of populations
Résumé
Pyrethroids are ubiquitous insecticides used in many areas such as agriculture, housing maintenance, and human or veterinary medicine. Over the last decade, biomonitoring studies have shown the wide exposure of human populations in many countries. The human biomarkers are usually the concentrations of pyrethroid metabolites in urine. The interpretation of these biomarkers to assess the environmental exposure of populations to a specific pyrethroid can be difficult since pyrethroids share metabolic pathways and common metabolites. In this work, we propose to develop a model that will link the exposure to three pyrethroids (permethrin, cypermethrin and cyfluthrin) to the urinary concentrations of their common metabolites (DCCA, 3-PBA and F-BPA).