Mixtures of Chemical Pollutants at European Legislation Safety Concentrations : How Safe Are They ? - Archive ouverte HAL Access content directly
Journal Articles Toxicological Sciences Year : 2014

Mixtures of Chemical Pollutants at European Legislation Safety Concentrations : How Safe Are They ?

(1) , , (2) , (2, 3) , (4) , , , (5) , (2) , (4) , (2) , (6) , (1) , , , , (6) , (5) , , (1) , , , , , (6) , (4) , (2, 3) , (7) , (7, 8) , , (6) , , , , (7) , , (5) , (1)
1
2
3
4
5
6
7
8
Augustine Arukwe
  • Function : Author
Anders Baun
  • Function : Author
Shimshon Belkin
  • Function : Author
Vesna Flander-Putrle
  • Function : Author
Maria Furhacker
  • Function : Author
Regina Grillari-Voglauer
  • Function : Author
Joubert B. Kharlyngdoh
  • Function : Author
Anne-Katrine Lungebye
  • Function : Author
Carina Modig
  • Function : Author
Per-Erik Olsson
  • Function : Author
Smitha Pillai
  • Function : Author
Susanna Sforzini
  • Function : Author
Liv Softeland
  • Function : Author
Valentina Turk
  • Function : Author
Aldo Viarengo
  • Function : Author
Sharon Yagur-Kroll
  • Function : Author

Abstract

The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.

Dates and versions

ineris-01855038 , version 1 (07-08-2018)

Identifiers

Cite

Raquel N. Carvalho, Augustine Arukwe, Selim Ait-Aissa, Anne Bado-Nilles, Stefania Balzamo, et al.. Mixtures of Chemical Pollutants at European Legislation Safety Concentrations : How Safe Are They ?. Toxicological Sciences, 2014, 141 (1), pp.218-233. ⟨10.1093/toxsci/kfu118⟩. ⟨ineris-01855038⟩
68 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More