Estrogènes, xénoestrogènes et neurogenèse chez le poisson-zèbre : un modèle sentinelle pertinent en santé humaine ?

Abstract : In zebrafish, radial glial cells (RGC), which are in fact neural stem cells, are directly sensitive to the presence of estrogen mimics in the water. RGC express aromatase, a product of the cyp19a1g gene under estrogenic stimulation. While embryos do not express this gene, very low concentrations of estrogens or estrogen mimics strongly activate aromatase expression in RGC. Estrogens and xenoestrogens inhibit the neurogenic activity in adult fish and embryos. Evaluating potential long-term consequences of these early effects requires thorough investigation not only in fish, but also in mammals. It is possible to use transgenic zebrafish tg(cyp19a1b-GFP) to detect estrogenic activities in vivo. The EASZY test is currently undergoing a validation procedure through the OECD (Organisation for Economic Co-operation and Development).
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Submitted on : Tuesday, August 7, 2018 - 1:40:26 PM
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  • HAL Id : ineris-01855039, version 1

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Olivier Kah, Elisabeth Pellegrini, Colette Vaillant, François Brion. Estrogènes, xénoestrogènes et neurogenèse chez le poisson-zèbre : un modèle sentinelle pertinent en santé humaine ?. Correspondances en Métabolismes, Hormones, Diabètes et Nutrition, Edimark, 2014, 18 (9), pp.258-261. ⟨ineris-01855039⟩

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