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Behavioral and biochemical effects of GSM 900MHz in neuroinflammation and gestational inflammation models

Abstract : The widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, GSM 900 MHz) on the brain. Effects of these EMFs during development stages and in vulnerability states as inflammation have been only poorly studied. Our aim was to assess EMF effects in adolescent rats subjected to neuroinflammation (Lipopolysaccharide (LPS) or artificial cerebrospinal fluid (aCSF) diffusion in lateral ventricle or in hippocampus (1.25 µg/h for 4 weeks from day 25) or to gestational inflammation (LPS or saline injection in peritoneum (0.1 mg/kg) on gestational day (GD) 15, GD17, and GD19). Sprague Dawley rats (32 days) were repeatedly exposed to various specific absorption rates (0, 1.5 or 6 W/kg; 45 min/d, 5 d/week, for 4 weeks). Endpoints were emotional memory, sensori-motor reactivity, exploration and anxiety (using fear conditioning, startle inhibition, open field and elevated plus maze) as well as cerebral Interleukine-1 beta (IL-1ß) and glial fibrillary acidic protein (GFAP). The neuro-inflammation model was characterized by increased levels of IL-1beta and GFAP, reduced startle level and by the increase of startle inhibition and the decrease of short term emotional memory. Gestational inflammation was linked to teratological effects, but no behavioral modifications. Effect of GSM exposures were shown by a decrease of GFAP in 1.5 W/kg-LPS compared to 0W/kg-LPS exposed rats. There was no GSM or LPS effect on anxiety. GSM EMFs at 900MHz did not induce neurobiological effects by itself and impacted only one biochemical parameter in vulnerable. These data suggest no specific vulnerability of adolescents with or without pre-existing inflammation in response to mobile phone EMF exposure.
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Nicolas Petitdant, Anthony Lecomte, Franck Robidel, Anne-Sophie Villegier. Behavioral and biochemical effects of GSM 900MHz in neuroinflammation and gestational inflammation models. 5. International Conference on Electromagnetic Fields, Health and Environment (EHE), Apr 2014, Porto, Portugal. ⟨ineris-01855472⟩



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