New tools for evidence-based risk assessment of chemical mixtures

Abstract : Risk assessment of chemical mixture has brought a number of scientific challenges, e.g. with respect to relevant data collection and robust quantitative methods to assess risks in humans. In this talk, the challenges will be presented in both regulatory and scientific viewpoints. Then, new tools for evidence-based risk assessment of chemical mixtures will be discussed in the context of the application of the systematic review methodology and meta-analysis to integrate metabolic interactions and toxicodynamic interactions for substances of priority in the food safety area. Examples of application and perspectives for embedding such techniques in routine risk assessment bodies will be presented.