Recommendations for a nanosafe production of nano-device involved in inflammatory disorders treatment

Abstract : NANOFOL is an European Project supported through the Seventh Framework Programme for Research and Technological Development. The project NANOFOL aimed to improve the treatment of chronic inflammatory diseases by the development and production of nanobiodevices (i.e. liposomes) in nanosafe conditions. As a result, a part of the Nanofol project is devoted to nanosafety management too with an aim of describing different operations which are used to deal with nano-risk during the use of dispersions containing nanoparticles. In the present communication, two parts of this work are discussed: the measurement campaign and the specific recommendations on nanosafety at a production site. A classical method to perform a complete measurement campaign consists of a preliminary campaign with a particle counter and a particle sampler. If necessary, it may be accompanied by a complementary campaign. This measurement strategy is described in INRS-CEA-INERIS guide [INERIS-INRS-CEA-, 2012]. One of the applications of this kind of methodology is to verify the absence of the nano-suspension aerosolization in the ambience through an accidental leakage which may occur during the production of the nano-suspension under pressure [Nogueira, 2013]. The preliminary campaign aims to check such leakage. To do so, two analyses, counting measurement and TEM grid sampling [R’mili, 2013] respectively, are carried out. While the counting measurement assesses an emission, the TEM grid sampling allows the morphological /chemical characterization of aerosol particles. The specific aspect of the recommendation part has to take into account percutaneous absorption risk induced by the liposome dispersion. For example Groso et al highlights the dispersant influence which facilitates the nanomaterials exposure [Groso, 2013]. It is possible to improve the nanosafety of the production site significantly by applying some modifications like carrying out each production step under a fume hood, particularly the filtration; purification of liposomes; implementation of double containment during each transport; labelled storage of nanomaterials etc. A proposition to simplify the nano-waste management has also been made. The producer could use such method to deal with their nano-waste more efficiently.
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Christophe Bressot, Neeraj Shandilya, Olivier Le Bihan, Olivier Aguerre-Chariol. Recommendations for a nanosafe production of nano-device involved in inflammatory disorders treatment. 4. International Conference on Safe Production and Use of Nanomaterials (Nanosafe 2014), Nov 2014, Grenoble, France. ⟨ineris-01855603⟩

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