, References

K. Kummerer, The presence of pharmaceuticals in the environment due to human use ??? present knowledge and future challenges, Journal of Environmental Management, vol.90, issue.8, pp.90-2354, 2009.
DOI : 10.1016/j.jenvman.2009.01.023

S. Maletz, In??vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents, Water Research, vol.47, issue.4, pp.1545-1557, 2013.
DOI : 10.1016/j.watres.2012.12.008

C. Kienle, R. Kase, and W. Werner, Evaluation of bioassays and wastewater quality: In vitro and in vivo bioassays for the performance review in the Project "Strategy MicroPoll, Swiss Centre for Applied Ecotoxicology, 2011.

S. C. Van-der-linden, Detection of Multiple Hormonal Activities in Wastewater Effluents and Surface Water, Using a Panel of Steroid Receptor CALUX Bioassays, Environmental Science & Technology, vol.42, issue.15, pp.42-5814, 2008.
DOI : 10.1021/es702897y

N. Creusot, Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples, Analytical and Bioanalytical Chemistry, vol.116, issue.2, pp.569-583, 2010.
DOI : 10.1007/s00216-009-3310-y
URL : https://hal.archives-ouvertes.fr/ineris-00453470

L. C. Santos, Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals. Science of The Total Environment, pp.2013-461

J. Rivera-utrilla, Pharmaceuticals as emerging contaminants and their removal from water. A review, Chemosphere, vol.93, issue.7, pp.1268-1287, 2013.
DOI : 10.1016/j.chemosphere.2013.07.059

, Acknowledgement -The study was funded in the frame of the French ANR-PANACEE project