Toxicokinetics of permethrin in the rat, Toxicology and Applied Pharmacology, vol.110, issue.1, pp.1-8, 1991. ,
DOI : 10.1016/0041-008X(91)90284-L
Urinary Concentrations of Pyrethroid Metabolites in the General US Population, Epidemiology, vol.19, pp.192-193, 1999. ,
Ways to fit a PK model with some data below the quantification limit, Journal of Pharmacokinetics and Pharmacodynamics, vol.28, issue.5, pp.481-504, 2001. ,
DOI : 10.1023/A:1012299115260
: A Monte Carlo Simulation Program, Journal of Statistical Software, vol.2, issue.9, 1997. ,
DOI : 10.18637/jss.v002.i09
Poisoning due to Pyrethroids, Toxicological Reviews, vol.16, issue.2, pp.93-106, 2005. ,
DOI : 10.1584/jpestics.11.9
Use of a Chemical Probe to Increase Safety for Human Volunteers in Toxicokinetic Studies, Risk Analysis, vol.120, issue.1-3, pp.1559-1571, 2005. ,
DOI : 10.1146/annurev.pa.32.040192.001153
URL : https://hal.archives-ouvertes.fr/ineris-00962971
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: Global sensitivity analysis for experimental design issues, Chemico-Biological Interactions, vol.167, issue.3, pp.168-183, 2007. ,
DOI : 10.1016/j.cbi.2007.02.010
Physiological Parameter Values for Physiologically Based Pharmacokinetic Models, Toxicology and Industrial Health, vol.191, issue.231, pp.407-484, 1997. ,
DOI : 10.1007/BF00184496
Quantitative Interpretation of Human Biomonitoring Data, Toxicology and Applied Pharmacology, vol.231, issue.1, pp.122-133, 2008. ,
DOI : 10.1016/j.taap.2008.04.021
A Novel Toxicokinetic Modeling of Cypermethrin and Permethrin and Their Metabolites in Humans for Dose Reconstruction from Biomarker Data, PLoS ONE, vol.62, issue.2, p.88517, 2014. ,
DOI : 10.1371/journal.pone.0088517.s002
Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal, liver and serum carboxylesterases, Toxicology and Applied Pharmacology, vol.221, issue.1, pp.1-12, 2007. ,
DOI : 10.1016/j.taap.2007.03.002
Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models, Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment, 2012. ,
DOI : 10.1021/bk-2012-1099.ch018
Biomonitoring of pyrethroid metabolites in environmental medicine, 2004. ,
Synthetic pyrethroid insecticides: a dermatological evaluation., Occupational and Environmental Medicine, vol.42, issue.6, pp.363-372, 1985. ,
DOI : 10.1136/oem.42.6.363
URL : http://oem.bmj.com/content/42/6/363.full.pdf
Permethrin metabolism in rats, Journal of Agricultural and Food Chemistry, vol.25, issue.1, pp.9-17, 1977. ,
DOI : 10.1021/jf60209a005
Posterior predictive assessment of model fitness via realized discrepancies, Stat Sinica, vol.6, pp.733-760, 1996. ,
Physiologically Based Pharmacokinetic Modeling of Deltamethrin: Development of a Rat and Human Diffusion-Limited Model, Toxicological Sciences, vol.48, issue.2, pp.330-343, 2010. ,
DOI : 10.1016/j.ntt.2007.01.007
Permethrin Emulsion Ingestion, Journal of Toxicology: Clinical Toxicology, vol.4, issue.1-2, pp.57-61, 1998. ,
DOI : 10.1021/jf60204a007
Clinical manifestations and diagnosis of acute pyrethroid poisoning, Archives of Toxicology, vol.2, issue.3, pp.54-58, 1989. ,
DOI : 10.1007/BF00334635
Reference values for metabolites of pyrethroid and organophosphorous insecticides in urine for human biomonitoring in environmental medicine, International Journal of Hygiene and Environmental Health, vol.209, issue.3, pp.293-299, 2006. ,
DOI : 10.1016/j.ijheh.2006.01.001
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance, Biochemical Pharmacology, vol.47, issue.9, pp.1469-1479, 1994. ,
DOI : 10.1016/0006-2952(94)90520-7
Uncertainty and variability in the exposure reconstruction of chemical incidents ??? the case of acrylonitrile, Toxicology Letters, vol.231, issue.3, pp.337-343, 2014. ,
DOI : 10.1016/j.toxlet.2014.07.019
Pyrethroid insecticide exposure and semen quality of young Japanese men, Reproductive Toxicology, vol.43, pp.38-44, 2014. ,
DOI : 10.1016/j.reprotox.2013.10.010
, Exposition de la population française aux substances chimiques de l'environnement. Tome 2 : Polychlorobiphényles et Pesticides, InVS, p.178, 2013.
Permethrin exposure during puberty has the potential to enantioselectively induce reproductive toxicity in mice, Environment International, vol.42, pp.144-151, 2012. ,
DOI : 10.1016/j.envint.2011.05.020
Determination of pyrethroid metabolites in human urine by capillary gas chromatography-mass spectrometry, Chromatographia, vol.33, issue.5-6, pp.285-292, 1996. ,
DOI : 10.1007/BF02270996
Pyrethroid toxicology: Mouse intracerebral structure-toxicity relationships, Pesticide Biochemistry and Physiology, vol.18, issue.1, pp.9-14, 1982. ,
DOI : 10.1016/0048-3575(82)90082-7
Simultaneous determination of five synthetic pyrethroid metabolites in urine by liquid chromatography???tandem mass spectrometry: Application to 39 persons without known exposure to pyrethroids, Toxicology Letters, vol.210, issue.2, pp.248-253, 2012. ,
DOI : 10.1016/j.toxlet.2011.08.016
URL : https://hal.archives-ouvertes.fr/inserm-00926148
Simultaneous determination of pyrethroid and pyrethrin metabolites in human urine by gas chromatography???high resolution mass spectrometry, Journal of Chromatography B, vol.814, issue.2, pp.285-294, 2005. ,
DOI : 10.1016/j.jchromb.2004.10.044
Transient Facial Sensory Symptoms Following Exposure to Synthetic Pyrethroids -a Clinical and Electro-Physiological Assessment, Neurotoxicology, vol.2, pp.1-11, 1981. ,
Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography???ion trap mass spectrometry, Analytical and Bioanalytical Chemistry, vol.397, issue.6, pp.3477-3487, 2014. ,
DOI : 10.1007/s00216-010-3786-5
URL : https://hal.archives-ouvertes.fr/ineris-01710209
Comparison of mouse and rat cytochrome P450- mediated metabolism in liver and intestine. Drug metabolism and disposition: the biological fate of chemicals 34, pp.1047-1054, 2006. ,
Human semen quality and sperm DNA damage in relation to urinary metabolites of pyrethroid insecticides, Human Reproduction, vol.148, issue.8, 1932. ,
DOI : 10.1210/en.2006-1497
Biotransformation and Enzymatic Reactions of Synthetic Pyrethroids in Mammals, Top curr chem, vol.314, pp.113-135, 2012. ,
DOI : 10.1007/128_2011_254
Development of a Physiologically Based Pharmacokinetic Model for Deltamethrin in the Adult Male Sprague-Dawley Rat, Toxicological Sciences, vol.93, issue.2, pp.432-442, 2006. ,
DOI : 10.1006/taap.2002.9432
Children???s Exposures to Pyrethroid Insecticides at Home: A Review of Data Collected in Published Exposure Measurement Studies Conducted in the United States, International Journal of Environmental Research and Public Health, vol.46, issue.8, pp.2964-2985, 2012. ,
DOI : 10.1021/es2044882
The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats, Toxicology, vol.235, issue.3, pp.176-184, 2007. ,
DOI : 10.1016/j.tox.2007.03.016
Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases, Biochemical Pharmacology, vol.71, issue.5, pp.657-669, 2006. ,
DOI : 10.1016/j.bcp.2005.11.020
ORGAN WEIGHTS AND FAT VOLUME IN RATS AS A FUNCTION OF STRAIN AND AGE, Journal of Toxicology and Environmental Health, Part A, vol.56, issue.7, pp.449-462, 1999. ,
DOI : 10.1080/009841099157917
In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms, Drug Metabolism and Disposition, vol.37, issue.1, pp.221-228, 2009. ,
DOI : 10.1124/dmd.108.022343
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances, Archives of Toxicology, vol.41, issue.2, pp.165-181, 2012. ,
DOI : 10.1016/S0896-6273(04)00116-3
Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment, Toxicology, vol.171, issue.1, pp.3-59, 2002. ,
DOI : 10.1016/S0300-483X(01)00569-8
Kinetics of Genistein and Its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration, Toxicological Sciences, vol.90, issue.1, pp.230-240, 2006. ,
DOI : 10.2174/1381612043383683
American Healthy Homes Survey: A National Study of Residential Pesticides Measured from Floor Wipes, Environmental Science & Technology, vol.43, issue.12, pp.4294-4300, 2009. ,
DOI : 10.1021/es8030243
-Permethrin and Its Major Metabolites, PBalc and PBacid, in Humans, Journal of Agricultural and Food Chemistry, vol.59, issue.9, pp.5001-5005, 2011. ,
DOI : 10.1021/jf200032q
A Pharmacokinetic Model of cis- and trans-Permethrin Disposition in Rats and Humans With Aggregate Exposure Application, Toxicological Sciences, vol.22, issue.1, pp.33-47, 2012. ,
DOI : 10.1038/jes.2012.12
Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites, Journal of Pesticide Science, vol.35, issue.2, pp.87-98, 2010. ,
DOI : 10.1584/jpestics.R10-01
Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women, Journal of Exposure Science & Environmental Epidemiology, vol.5, issue.6, pp.601-609, 2012. ,
DOI : 10.1007/s10653-011-9382-6
URL : https://hal.archives-ouvertes.fr/ineris-00963410
Overview of Permethrin Risk Assessment, U.S. Environmental Protection Agency, 2005. ,
Pesticides Industry Sales and Usage : 2006 and, Market Estimates. U.S. Environmental Protection Agency, 2007. ,
Alteration of infant attention and activity by polychlorinated biphenyls: Unravelling critical windows of susceptibility using physiologically based pharmacokinetic modeling, NeuroToxicology, vol.31, issue.5, pp.424-431, 2010. ,
DOI : 10.1016/j.neuro.2010.05.011
Structure-activity relationships of some pyrethroids in rats, Archives of Toxicology, vol.6, issue.5450, pp.325-329, 1980. ,
DOI : 10.1007/BF00293813
Thermoregulation of the Scrotum and Testis: Studies in Animals and Significance for Man, Adv Exp Med Biol, vol.286, pp.9-17, 1991. ,
DOI : 10.1007/978-1-4684-5913-5_2
Studying permethrin exposure in flight attendants using a physiologically based pharmacokinetic model, Journal of Exposure Science & Environmental Epidemiology, vol.1, issue.4, pp.416-427, 2013. ,
DOI : 10.1038/sj.jea.7500257
Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment, Toxicological sciences : an official journal of the Society of Toxicology, pp.157-174, 2012. ,
DOI : 10.1289/ehp.0800404
In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes, Toxicology in Vitro, vol.29, issue.4, pp.803-812, 2015. ,
DOI : 10.1016/j.tiv.2015.03.003
URL : https://hal.archives-ouvertes.fr/ineris-01855035
Neurobehavioral toxicology of pyrethroid insecticides in adult animals: A critical review, Neurotoxicology and Teratology, vol.30, issue.2, pp.55-78, 2008. ,
DOI : 10.1016/j.ntt.2007.10.005
The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration, Xenobiotica, vol.27, issue.2, pp.983-991, 1992. ,
DOI : 10.1021/jf60222a059
Environmental exposure to pyrethroids and sperm sex chromosome disomy: a cross-sectional study, Environmental Health, vol.12, issue.1, 2013. ,
DOI : 10.1038/aja.2009.85
Lack of P-Glycoprotein-Mediated Efflux and the Potential Involvement of an Influx Transport Process Contributing to the Intestinal Uptake of Deltamethrin, cis-Permethrin, and trans-Permethrin, Toxicological Sciences, vol.21, issue.2, pp.284-293, 2013. ,
DOI : 10.1023/B:PHAM.0000036925.45002.a2
Exposure assessment of phthalates in French pregnant women: Results of the ELFE pilot study, International Journal of Hygiene and Environmental Health, vol.216, issue.3, pp.271-279, 2013. ,
DOI : 10.1016/j.ijheh.2012.12.005
URL : https://hal.archives-ouvertes.fr/ineris-00963467
Permethrin may induce adult male mouse reproductive toxicity due to cis isomer not trans isomer, Toxicology, vol.248, issue.2-3, pp.136-141, 2008. ,
DOI : 10.1016/j.tox.2008.03.018
Permethrin May Disrupt Testosterone Biosynthesis via Mitochondrial Membrane Damage of Leydig Cells in Adult Male Mouse, Endocrinology, vol.148, issue.8, pp.3941-3949, 2007. ,
DOI : 10.1210/en.2006-1497
, Fat:blood (PCfat) 150 ± 75, pp.171-301
, GI:blood (PCgi) Equal to PCkid Equal to PCkid - - Kidney:blood (PCkid) 0.4 ± 0
, Liver:blood, p.89
, Muscle:blood (PCmus), vol.6, issue.3
, Testes:blood (PCtes) 0.4 ± 0.2 [10 -3 -30] Equal to PCbra 0, p.63
, 54 -0.72] - Rapidly perfused:blood (PCrp) Equal to PCkid Equal to PCkid - - Slowly perfused:blood (PCsp), pp.6-9
Brain (PAbra) 10 -3 ± 10 -3 ,
, Fat
, Muscles
, Testes (PAtes) 10 -3 ± 10 -3
, Equal to PAbra/3 3, pp.10-14
, 4 ] - Slowly perfused (PAsp) 0.1 ± 0
, Rate constants (h -1 ) Stomach-intestine transfer (Ksi) 0
, 17 -0.23] Intestinal absorption (Kint) 0
, 68 -1.06] Metabolic clearances GI metabolism
, Kblo) Fixed to 0.07 Fixed to 0.29 - - Liver metabolism, Blood
, 2 -3.3] - - Permeability coefficients (L/h) Rest of body:blood (PArb)
, 18 -0.34] - - Fraction of metabolite formed Fraction (Fracmet)
, Rate constants Fecal excretion (h -1 ) (Kfec) 0
, Cis-permethrin Partition coefficients Liver:blood (PCliv) 10 ± 5 [1 -30
, 3 -7.6] - - Rest of body:blood (PCrb) 10 ± 5 [1 -30
, 7 -4.1] - - Permeability coefficients (L/h) Rest of body:blood (PArb)
, 72 -0.98] - - Fraction of metabolite formed Fraction (Fracmet)
, Rate constants Fecal excretion (h -1 ) (Kfec) 0
, 103] a : the urine clearance of the DCCA is expressed in L/h and the rate of urine elimination of 3-PBA and 4'-OH-PBA in h, p.1