In vitro screening for population variability in toxicity of pesticide-containing mixtures, Environment International, vol.85, pp.147-155, 2015. ,
DOI : 10.1016/j.envint.2015.09.012
Population-Based in Vitro Hazard and Concentration???Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study, Environmental Health Perspectives, vol.123, pp.458-466, 2015. ,
DOI : 10.1289/ehp.1408775
Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment, Toxicology, vol.332, pp.102-111, 2015. ,
DOI : 10.1016/j.tox.2014.02.007
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment, Environmental Toxicology and Chemistry, vol.38, issue.3, pp.730-741, 2010. ,
DOI : 10.1201/9780203647295.ch2
CROSS-SPECIES CONSERVATION OF ENDOCRINE PATHWAYS: A CRITICAL ANALYSIS OF TIER 1 FISH AND RAT SCREENING ASSAYS WITH 12 MODEL CHEMICALS, Environmental Toxicology and Chemistry, vol.86, issue.5, pp.1084-1087, 2013. ,
DOI : 10.1093/toxsci/kfi202
Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential, Environmental Health Perspectives, vol.123, pp.49-56, 2015. ,
DOI : 10.1289/ehp.1408642
The Tox21 robotic platform for the assessment of environmental chemicals ??? from vision to reality, Drug Discovery Today, vol.18, issue.15-16, pp.716-723, 2013. ,
DOI : 10.1016/j.drudis.2013.05.015
A computational approach to chemical etiologies of diabetes, Scientific Reports, vol.27, issue.1, p.2712, 2013. ,
DOI : 10.1093/bioinformatics/btq675
Integrating Publicly Available Data to Generate Computationally Predicted Adverse Outcome Pathways for Fatty Liver, Toxicological Sciences, vol.6, issue.2, pp.510-520, 2016. ,
DOI : 10.1080/713611034
Identification and Prioritization of Relationships between Environmental Stressors and Adverse Human Health Impacts, Environmental Health Perspectives, vol.123, issue.11, pp.1193-1199, 2015. ,
DOI : 10.1289/ehp.1409138
Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals, Regulatory Toxicology and Pharmacology, vol.72, issue.2, pp.292-309, 2015. ,
DOI : 10.1016/j.yrtph.2015.04.010
Genotype to phenotype via network analysis, Current Opinion in Genetics & Development, vol.23, issue.6, pp.611-621, 2013. ,
DOI : 10.1016/j.gde.2013.10.003
URL : https://doi.org/10.1016/j.gde.2013.10.003
A new path forward: the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), J Am Assoc Lab Anim Sci, vol.54, issue.2, pp.170-173, 2015. ,
Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2, Oxid Med Cell Longev, vol.2013, pp.254069-254079, 2013. ,
Advancing the Next Generation of Health Risk Assessment, Environmental Health Perspectives, vol.120, issue.11, pp.1499-1502, 2012. ,
DOI : 10.1289/ehp.1104870
Developing scientific confidence in HTS-derived prediction models: Lessons learned from an endocrine case study, Regulatory Toxicology and Pharmacology, vol.69, issue.3, pp.443-450, 2014. ,
DOI : 10.1016/j.yrtph.2014.05.010
The Role of Advanced Biological Data in the Rationality of Risk-Based Regulatory Decisions, Journal of Environmental Protection, vol.04, issue.03, pp.238-249, 2013. ,
DOI : 10.4236/jep.2013.43028
Fundamental carcinogenic processes and their implications for low dose risk assessment, Cancer Res, vol.369, issue.1, pp.2973-2979, 1976. ,
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015, Nucleic Acids Research, vol.33, issue.D1, pp.914-920, 2015. ,
DOI : 10.1016/j.reprotox.2011.10.018
URL : https://academic.oup.com/nar/article-pdf/43/D1/D914/7330511/gku935.pdf
Virtual Models (vM), pp.948-957, 2014. ,
DOI : 10.1016/B978-0-12-386454-3.01059-9
Department of Health and Human Services) 2014. The Health Consequences of Smoking?50 years of Progress GA:DHHS, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, 2016. ,
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk, Front Pharmacol, vol.3204, 2013. ,
URL : https://hal.archives-ouvertes.fr/ineris-00961795
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity, Diabetes, vol.63, issue.6, pp.2158-2171, 2014. ,
DOI : 10.2337/db13-0949
Cultured Basal Airway Epithelial Cells From Asthmatics Display Baseline Gene Expression Profiles That Differ From Normal Healthy Cells And Exhibit Differential Responses To Ambient Air Pollution Particles, C37. MEDIATORS OF ASTHMA AND ALLERGIC LUNG DISEASE, 2012. ,
DOI : 10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A4291
, 2016 SEURAT-1: Towards the Replacement of in Vivo Repeated Dose Systemic Toxicity Testing, EC, 2016.
Joint Research Centre) 2015 Validation and Regulatory Acceptance of Alternative Methods and Approaches (2015) http://bookshop.europa.eu/en/ eurl-ecvam-status-report-on-the-development- validation-and-regulatory-acceptance-of- alternative-methods-and-approaches, EURL ECVAM Status Report on the Development, 2015. ,
European Chemical Agency). 2016a ECHA News: The QSAR Toolbox, 2016. ,
, , 2016.
Prediction of human population responses to toxic compounds by a collaborative competition, Nature Biotechnology, vol.123, issue.9, pp.933-940, 2015. ,
DOI : 10.1021/ci100050t
URL : https://hal.archives-ouvertes.fr/hal-01428019
Possible molecular mechanisms linking air pollution and asthma in children, BMC Pulmonary Medicine, vol.41, issue.742, pp.31-41, 2014. ,
DOI : 10.1111/j.1365-2222.2011.03790.x
URL : https://bmcpulmmed.biomedcentral.com/track/pdf/10.1186/1471-2466-14-31
Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform, Current Chemical Genomics and Translational Medicine, vol.8, issue.1, pp.36-46, 2014. ,
DOI : 10.2174/2213988501408010036
Diversity outbred mice identify population-based exposure thresholds and genetic factors that influence benzene-induced genotoxicity, Environ Health Perspect, vol.123, pp.237-245, 2015. ,
DOI : 10.1289/ehp.1408202
URL : http://europepmc.org/articles/pmc4348743?pdf=render
Scientific opportunities from heterogeneous biological data analysis: overcoming complexity. Presentation. National Academy of Sciences Meeting: Integrating Environmental Health Data to Advance Discovery, pp.10-11, 2013. ,
Are Adverse Outcome Pathways Here to Stay?, Environmental Science & Technology, vol.49, issue.1, pp.3-9, 2015. ,
DOI : 10.1021/es504976d
URL : https://doi.org/10.1021/es504976d
The NCBI BioSystems database, Nucleic Acids Research, vol.37, issue.suppl_1, pp.492-496, 2010. ,
DOI : 10.1093/nar/gkp456
URL : https://academic.oup.com/nar/article-pdf/38/suppl_1/D492/11217780/gkp858.pdf
Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk, Mutagenesis, vol.22, issue.4, pp.733-742, 2015. ,
DOI : 10.1158/1055-9965.EPI-13-0146
Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells, PLoS One, vol.124, issue.76, p.39205, 2012. ,
Predictive QSAR modeling: methods and applications in drug discovery and chemical risk assessment, In: Handbook of Computational Chemistry (Leszczynski J, pp.1309-1342, 2012. ,
DOI : 10.1007/978-3-319-27282-5_37
Informing Mechanistic Toxicology with Computational Molecular Models, Methods Mol Biol, vol.929, pp.139-165, 2012. ,
DOI : 10.1007/978-1-62703-050-2_7
Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel, Toxicological Sciences, vol.278, issue.1, pp.235-243, 2009. ,
DOI : 10.1074/jbc.M208470200
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans, Genome Research, vol.19, issue.9, pp.1507-1515, 2009. ,
DOI : 10.1101/gr.090241.108
Progress in Assessing Air Pollutant Risks from In Vitro Exposures: Matching Ozone Dose and Effect in Human Airway Cells, Toxicological Sciences, vol.276, issue.6 Pt 1, pp.198-205, 2014. ,
DOI : 10.3109/01902149309064358
Cancer Epigenetics: New Therapies and New Challenges, Journal of Drug Delivery, vol.32, issue.5, p.529312, 2013. ,
DOI : 10.1038/onc.2008.436
URL : http://downloads.hindawi.com/journals/jdd/2013/529312.pdf
Systems Approaches to Biology and Disease Enable Translational Systems Medicine, Genomics, Proteomics & Bioinformatics, vol.10, issue.4, pp.181-185, 2012. ,
DOI : 10.1016/j.gpb.2012.08.004
URL : https://doi.org/10.1016/j.gpb.2012.08.004
Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor, Scientific Reports, vol.4, issue.1, 2014. ,
DOI : 10.1038/srep05664
URL : https://www.nature.com/articles/srep06437.pdf
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway, Scientific Reports, vol.3, issue.1, p.5664, 2014. ,
DOI : 10.1126/scitranslmed.3001862
Modelling the Tox21 10???K chemical profiles for in vivo toxicity prediction and mechanism characterization, Nature Communications, vol.39, p.10425, 2016. ,
DOI : 10.1016/j.neunet.2006.05.001
Biologically Relevant Exposure Science for 21st Century Toxicity Testing, Toxicological Sciences, vol.24, issue.2, pp.226-232, 2009. ,
DOI : 10.1158/1055-9965.EPI-05-0456
, International Agency for Research on Cancer). 2010. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures, IARC IARC Monogr Eval Carcinog Risk Hum, vol.92
, IARC. 2012. Benzene. IARC Monogr Eval Carcinog Risk Hum, vol.100, pp.249-294
Differential network biology, Molecular Systems Biology, vol.11, p.565, 2012. ,
DOI : 10.1038/msb.2009.80
Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals, Environmental Health and Preventive Medicine, vol.304, issue.3, pp.185-197, 2013. ,
DOI : 10.1016/j.mce.2009.02.021
, 2016 Alternatives to Animal Testing and Safety Assessment of Chemicals. https://ec.europa.eu/jrc/en/researchtopic/alternatives-animal-testing-and-safetyassessment-chemicals, JRC, 2016.
and Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme, Basic & Clinical Pharmacology & Toxicology, vol.6, issue.1, pp.69-76, 2014. ,
DOI : 10.1371/journal.pcbi.1000756
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing, ALTEX, vol.30, issue.1, pp.51-66, 2013. ,
DOI : 10.14573/altex.2013.1.051
Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment, Chemical Research in Toxicology, vol.24, issue.4, pp.451-462, 2011. ,
DOI : 10.1021/tx100428e
High-Throughput Screening Assays for the Estrogen Receptor, Toxicological Sciences, vol.47, issue.1, pp.137-154, 2015. ,
DOI : 10.1093/nar/gkm958
Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System, International Journal of Molecular Sciences, vol.9, issue.Database issue, pp.1805-1831, 2012. ,
DOI : 10.1016/j.envsci.2005.11.011
Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity, Environmental Science & Technology, vol.44, issue.15, pp.5979-5985, 2010. ,
DOI : 10.1021/es102150z
ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.274, issue.7, pp.736-746, 2015. ,
DOI : 10.1183/09031936.00125010
Update on EPA???s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management, Chemical Research in Toxicology, vol.25, issue.7, pp.1287-1302, 2012. ,
DOI : 10.1021/tx3000939
Adverse outcome pathways: From research to regulation scientific workshop report, Regulatory Toxicology and Pharmacology, vol.76, pp.39-50, 2016. ,
DOI : 10.1016/j.yrtph.2016.01.007
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms, Nature Biotechnology, vol.161, issue.6, pp.583-591, 2014. ,
DOI : 10.1016/S1093-3263(00)00065-6
Systems Modeling in Developmental Toxicity, Handbook of Systems Toxicology, 2011. ,
DOI : 10.1093/toxsci/kfj184
, , pp.599-617
FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology, Toxicological Sciences, vol.121, issue.2, pp.256-267, 2015. ,
DOI : 10.1021/tx400226u
Predictive Models and Computational Toxicology, Methods Mol Biol, vol.947, pp.343-374, 2013. ,
DOI : 10.1007/978-1-62703-131-8_26
New Directions in Toxicity Testing, Annual Review of Public Health, vol.32, issue.1, pp.161-178, 2011. ,
DOI : 10.1146/annurev-publhealth-031210-101153
A Framework for the Next Generation of Risk Science, Environmental Health Perspectives, vol.122, pp.796-805, 2014. ,
DOI : 10.1289/ehp.1307260
Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.369, issue.1656, 2014. ,
DOI : 10.1098/rstb.2013.0576
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research, Environmental Health Perspectives, vol.123, issue.11, pp.268-272, 2015. ,
DOI : 10.1289/ehp.1510345
Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model, Toxicological Sciences, vol.116, issue.2, pp.578-588, 2012. ,
DOI : 10.1093/bioinformatics/btr449
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project, Environmental Health Perspectives, vol.124, issue.7, pp.1023-1033, 2016. ,
DOI : 10.1289/ehp.1510267
Biomarkers of Tobacco Smoke Exposure, Adv Clin Chem, vol.67, pp.1-45, 2014. ,
DOI : 10.1016/bs.acc.2014.09.001
Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment, PLoS ONE, vol.28, issue.12, p.110379, 2014. ,
DOI : 10.1371/journal.pone.0110379.t005
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression, Toxicological Sciences, vol.15, issue.6, pp.216-224, 2016. ,
DOI : 10.1016/j.freeradbiomed.2011.05.006
Ozone Induces a Proinflammatory Response in Primary Human Bronchial Epithelial Cells through Mitogen-Activated Protein Kinase Activation Without Nuclear Factor-??B Activation, American Journal of Respiratory Cell and Molecular Biology, vol.2013, issue.3, pp.426-435, 2014. ,
DOI : 10.1074/jbc.M112.444182
Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human, Annals of the New York Academy of Sciences, vol.184, issue.742, 2014. ,
DOI : 10.1016/j.cbi.2009.12.011
, Ann N Y Acad Sci, vol.1310, pp.74-83
Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels, Environmental Health Perspectives, vol.119, issue.5, pp.628-634, 2011. ,
DOI : 10.1289/ehp.1002546
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment, Carcinogenesis, vol.312, issue.5776, pp.240-252, 2012. ,
DOI : 10.1126/science.312.5776.998a
Transcriptional profiling to identify biomarkers of disease and drug response, Pharmacogenomics, vol.2, issue.2, pp.235-249, 2011. ,
DOI : 10.1007/978-1-60327-048-9_11
Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century, Toxicology and Applied Pharmacology, vol.271, issue.3, pp.395-404, 2013. ,
DOI : 10.1016/j.taap.2011.01.015
, Technical Working Group on Pesticides) 2012. (Q)uantitative Structure Activity Relationship [(Q)SAR] Guidance Document. https://www.epa. gov/sites, pp.2016-2017, 2016.
, National Human Genome Research Institute). 2015. A Catalog of Published Genome-Wide Association Studies, NHGRI, 2016.
, 2015. NIEHS Single Nucleotide Polymorphisms (SNPs) Environmental Genome Project, NIEHS, 2016.
Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform, Mutagenesis, vol.1400, pp.69-81, 2016. ,
DOI : 10.1038/nprot.2007.77
, Toxicity Testing in the 21st Century: A Vision and a Strategy, NRC, 2007.
Science and Decisions: Advancing Risk Assessment, 2009. ,
Predicting Later-Life Outcomes of Early- Life Exposures [news story]. Standing Committee on Use of Emerging Science for Environmental Health Decisions Newsletter, Emerging Science for Environmental Health Decisions, 2011. ,
Review of EPA's Integrated Risk Information System (IRIS) Process, 2014. ,
, 2013. Guidance Document on Developing and Assessing Adverse Outcome Pathways Available: http://search.oecd, Series on Testing and Assessment, pp.282013-296, 2013.
Version 3.0, 2016. ,
Other Activities on Molecular Screening and Toxicogenomics, 2016. ,
In Vitro Screening for Population Variability in Chemical Toxicity, Toxicological Sciences, vol.237, issue.2, pp.398-407, 2011. ,
DOI : 10.1016/j.tox.2007.05.004
Zebrafish developmental screening of the ToxCast??? Phase I chemical library, Reproductive Toxicology, vol.33, issue.2, pp.174-187, 2012. ,
DOI : 10.1016/j.reprotox.2011.10.018
What do the data show? Knowledge map development for comprehensive environmental assessment, Integrated Environmental Assessment and Management, vol.31, issue.1, pp.37-47, 2014. ,
DOI : 10.1111/j.1539-6924.2011.01767.x
Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease, Bioinformatics, vol.316, issue.5829, pp.121-126, 2012. ,
DOI : 10.1126/science.1142364
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus, Human Genetics, vol.414, issue.5, pp.495-508, 2013. ,
DOI : 10.1038/414782a
Whole genome sequencing in support of wellness and health maintenance, Genome Medicine, vol.5, issue.6, 2013. ,
DOI : 10.1371/journal.pone.0059494
, Genome Med, vol.558
Current perspectives on the use of alternative species in human health and ecological risk assessments, Environ Health Perspect, vol.121, pp.1002-1010, 2013. ,
Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods, Toxicology and Applied Pharmacology, vol.280, issue.1, pp.177-189, 2014. ,
DOI : 10.1016/j.taap.2014.07.009
Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells, Chemical Research in Toxicology, vol.26, issue.7, pp.1097-1107, 2013. ,
DOI : 10.1021/tx400117y
Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening, Toxicological Sciences, vol.117, issue.2, pp.348-358, 2010. ,
DOI : 10.1289/ehp.0800404
Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data, Toxicological Sciences, vol.99, issue.1, pp.1-9, 2012. ,
DOI : 10.1093/toxsci/kfm131
Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity, NeuroToxicology, vol.53, pp.271-281, 2016. ,
DOI : 10.1016/j.neuro.2016.02.003
NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care, Science Translational Medicine, vol.41, issue.4, 2012. ,
DOI : 10.1038/ng.325
URL : http://stm.sciencemag.org/content/4/115/115rv1.full.pdf
Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing, J Am Assoc Lab Anim Sci, vol.54, issue.2, pp.214-223, 2015. ,
Virtual Tissues in Toxicology, Journal of Toxicology and Environmental Health, Part B, vol.2, issue.2-4, pp.314-328, 2010. ,
DOI : 10.1002/hep.510270427
Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays, Chemical Research in Toxicology, vol.26, issue.6, pp.878-895, 2013. ,
DOI : 10.1021/tx400021f
URL : https://doi.org/10.1021/tx400021f
Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data, Toxicological Sciences, vol.31, issue.1, pp.109-127, 2011. ,
DOI : 10.1007/s11259-007-3551-1
Zebrafish-As an integrative model for twenty-first century toxicity testing, Birth Defects Research Part C: Embryo Today: Reviews, vol.281, issue.pt 1, pp.256-267, 2011. ,
DOI : 10.1016/j.tox.2011.01.004
Advances in Understanding Benzene Health Effects and Susceptibility, Annual Review of Public Health, vol.31, issue.1, pp.133-148, 2010. ,
DOI : 10.1146/annurev.publhealth.012809.103646
URL : https://www.annualreviews.org/doi/pdf/10.1146/annurev.publhealth.012809.103646
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis, Environmental Health Perspectives, vol.124, issue.6, pp.713-721, 2016. ,
DOI : 10.1289/ehp.1509912
Benzene, the exposome and future investigations of leukemia etiology, Chemico-Biological Interactions, vol.192, issue.1-2, pp.155-159, 2011. ,
DOI : 10.1016/j.cbi.2011.02.010
Role of Environmental Chemicals in Diabetes and Obesity: A National Toxicology Program Workshop Review, Environmental Health Perspectives, vol.120, issue.6, pp.779-789, 2012. ,
DOI : 10.1289/ehp.1104597
Zebrafish Eleutheroembryos Provide a Suitable Vertebrate Model for Screening Chemicals that Impair Thyroid Hormone Synthesis, Environmental Science & Technology, vol.45, issue.17, pp.7525-7532, 2011. ,
DOI : 10.1021/es202248h
URL : https://digital.csic.es/bitstream/10261/87764/1/accesoRestringido.pdf
Characterization of Changes in Gene Expression and Biochemical Pathways at Low Levels of Benzene Exposure, PLoS ONE, vol.15, issue.5, p.91828, 2014. ,
DOI : 10.1371/journal.pone.0091828.s007
Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology, Environmental and Molecular Mutagenesis, vol.184, issue.suppl 1, pp.566-573, 2013. ,
DOI : 10.1016/j.cbi.2009.12.011
Using Bioinformatic Approaches to Identify Pathways Targeted by Human Leukemogens, International Journal of Environmental Research and Public Health, vol.2, issue.2, pp.2479-2503, 2012. ,
DOI : 10.1162/089976601750264965
URL : https://www.mdpi.com/1660-4601/9/7/2479/pdf
A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening, Toxicological Sciences, vol.116, issue.2, pp.398-417, 2012. ,
DOI : 10.1080/15287390490471479
Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment, Toxicological Sciences, vol.24, issue.1, pp.194-205, 2011. ,
DOI : 10.1093/molbev/msm061
Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.746, issue.2, pp.135-143, 2012. ,
DOI : 10.1016/j.mrgentox.2012.01.007
Cross-Species Transcriptomic Analysis of Mouse and Rat Lung Exposed to Chloroprene, Toxicological Sciences, vol.26, issue.136, pp.629-640, 2013. ,
DOI : 10.1016/j.tiv.2012.04.004
Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework, Toxicological Sciences, vol.125, issue.1, pp.4-18, 2013. ,
DOI : 10.1093/toxsci/kfr254
URL : https://academic.oup.com/toxsci/article-pdf/136/1/4/11011562/kft178.pdf
Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment, Toxicological Sciences, vol.8, issue.1, pp.180-194, 2013. ,
DOI : 10.1186/1471-2164-8-387
Improving the Human Hazard Characterization of Chemicals: A Tox21 Update, Environmental Health Perspectives, vol.121, issue.7, pp.756-765, 2013. ,
DOI : 10.1289/ehp.1205784
Applying Adverse Outcome Pathways (AOPs), 2014. ,
, Regul Toxicol Pharmacol, vol.70, pp.629-640
, Environmental Protection Agency). 2011a Advancing the Next Generation (NexGen) of Risk Assessment: The Prototypes Workshop. 1?3, 2010.
Advancing the Next Generation (NexGen) of Risk Assessment: Public Dialogue Conference, 2016. ,
Endocrine Disrupter Sceening Program for the 21st Century: (EDSP21 Work Plan). The Incorporation of In Silico Models and In vitro High Throughput Assays in the Endocrine Disruptor Screening Program (EDSP) for Prioritization and Screening, 2011. ,
Use of " Omic " Technology to Inform the Risk Assessment Support Document for Case Study, 2016. ,
Final Report: Integrated Science Assessment of Ozone and Related Photochemical Oxidants. EPA/600/R-10/076, 2016. ,
IRIS Toxicological Review of Benzo[a] pyrene (Public Comment Draft), 2013. ,
Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (Final Report) EPA, 2014. ,
Chemical Safety for Sustainability: Strategic Research Action Plan 2016-2019 EPA 601/K-15/003. https://www.epa.gov/research/ chemical-safety-sustainability-strategic-research- action-plan, 2016. ,
Human Health Risk Assessment: Strategic Research Action Plan 2016-2019 EPA 601/K-15/002. https://www.epa.gov/research/ human-health-risk-assessment-strategic-research- action-plan, 2016. ,
TSCA Chemical Substance Inventory, 2016. ,
Science in Action Innovative Research for a Sustainable Future Computational Toxicology Research [fact sheet]. https://www.epa.gov/sites/ production, pp.2016-2019, 2016. ,
Developmental Toxicity Prediction, Methods Mol Biol, vol.930, pp.305-340, 2013. ,
DOI : 10.1007/978-1-62703-059-5_14
Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China, Ann Occup Hyg, vol.48, pp.105-116, 2004. ,
Investigating Alternatives to the fish early-life stage test: A strategy for discovering and annotating adverse outcome pathways for early fish development, Environmental Toxicology and Chemistry, vol.50, issue.125, pp.158-169, 2014. ,
DOI : 10.1002/hep.23157
The adverse outcome pathway concept: A pragmatic tool in toxicology, Toxicology, vol.312, pp.158-165, 2013. ,
DOI : 10.1016/j.tox.2013.08.011
Toxicokinetic Triage for Environmental Chemicals, Toxicological Sciences, vol.18, issue.4, pp.55-67, 2015. ,
DOI : 10.1016/j.tiv.2013.10.023
URL : http://europepmc.org/articles/pmc4560038?pdf=render
Application of computational toxicological approaches in human health risk assessment. I. A tiered surrogate approach, Regulatory Toxicology and Pharmacology, vol.63, issue.1, pp.10-19, 2012. ,
DOI : 10.1016/j.yrtph.2012.02.006
An in silico approach for evaluating a fraction-based, risk assessment method for total petroleum hydrocarbon mixtures, J Toxicol, vol.2012, pp.410143-410153, 2012. ,
Development of quantitative structure-activity relationship (QSAR) models to predict the carcinogenic potency of chemicals . II. Using oral slope factor as a measure of carcinogenic potency, Regul Toxicol Pharmacol, vol.59, pp.215-226, 2011. ,
"Good Enough Solutions" and the Genetics of Complex Diseases, Circulation Research, vol.111, issue.4, pp.493-504, 2012. ,
DOI : 10.1161/CIRCRESAHA.112.269084
Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays, Toxicological Sciences, vol.27, issue.2, pp.327-346, 2013. ,
DOI : 10.1093/toxsci/kfr254
Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment, Toxicological Sciences, vol.117, issue.1, pp.157-174, 2012. ,
DOI : 10.1289/ehp.0800404
Src-Mediated EGF Receptor Activation Regulates Ozone-Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells, Environmental Health Perspectives, vol.123, pp.231-236, 2015. ,
DOI : 10.1289/ehp.1307379
Computational tools for discovery and interpretation of expression quantitative trait loci, Pharmacogenomics, vol.3, issue.3, pp.343-352, 2012. ,
DOI : 10.1038/ng.2007.57
Emerging approaches in predictive toxicology, Environmental and Molecular Mutagenesis, vol.741, issue.742, pp.679-688, 2014. ,
DOI : 10.1016/j.mrfmmm.2013.01.002
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.21885
Addressing human variability in nextgeneration human health risk assessments of environmental chemicals, Environ Health Perspect, vol.121, pp.23-31, 2013. ,
URL : https://hal.archives-ouvertes.fr/ineris-00961796