Cohorte MecoExpo : utilisation du méconium pour estimer l’exposition in utero aux pesticides des nouveau-nés en Picardie

Abstract : The MecoExpo study was conducted in Picardy, an agricultural region where pesticides are used. This study was designed to evaluate the relationship between parental and fetal exposure to pesticides. Neonatal anthropomorphic parameters were compared to parental pesticide exposure during pregnancy. Parental exposure to pesticides was assessed by means of a validated questionnaire. In utero fetal exposure was assessed for the first time in France by means of neonatal meconium assays. Nine-hundred and ninety-three mother-newborn pairs were included. A significant relationship was observed between maternal occupational exposure to pesticides and low birth weight for gestational age. An association was also observed between preterm birth and paternal exposure to pesticides. At least one pesticide was detected on meconium screening in 85% of newborns. The pesticides most frequently detected were organophosphorus and carbamate metabolites. These pesticides are commonly used for extensive field treatments in Picardy. A significant relationship was observed between maternal and paternal occupational exposure to pesticides and neonatal anthropomorphic parameters. Positive screening for pesticides in the meconium of newborns was assessed for the first time in France.
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Submitted on : Wednesday, August 29, 2018 - 11:17:43 AM
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Pierre Tourneux, Flora Mayhoub, E. Haraux, C. Deguines, Thierry Berton, et al.. Cohorte MecoExpo : utilisation du méconium pour estimer l’exposition in utero aux pesticides des nouveau-nés en Picardie. Revue de médecine périnatale, Springer Link 2014, 6 (2), pp.122-133. ⟨10.1007/s12611-014-0277-5⟩. ⟨ineris-01863946⟩

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