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The Application of Ecotoxicological Tools to Safer-by-Design Strategies for Engineered Nanomaterials

Abstract : OECD test guidelines using aquatic organisms have been identified as suitable starting points for identifying risk that engineered nanomaterials (ENMs) risk represent for the environment. However, standardized testing (mainly relevant for freshwater species) may not be able to adequately characterize the risk and dynamic behavior of ENMs in the environment, in particular for aquatic regions like coastal areas which are the ultimate sink for all land based contaminants. As a result, the addition of less conventional organisms to regulatory projects can promote the characterization of environmental risk nanomaterials pose. Mytilus species have a long history of being used as sentinel organisms to characterize ecosystem health and can be used to promote the understanding of environmental risk that emerging contaminants like ENMs pose. This information can be particularly useful for the development of safer-by-design strategies as implementation in risk characterization can promote the identification of which products an industry creates pose the lowest environmental risk. In this context, under project the Horizon 2020 project NanoReg2, the aim of this study was to demonstrate the implementation of a safer-by-design strategy for ENM development. Three carbon nanofibers (CNFs) were provided by an industrial partner in order to characterize the potential environmental risk their products posed. The aim of the study was to compare the original product (GANF) to a new scaled up production process for the CNF (GATam) as well a graphitized verison of the product (GANFg). The study implemented regulatory testing using Daphnia magna and Pseudokirchneriella subcapitata as well as hemocytes from the marine mussel Mytilus edulis (M. edulis) following in vitro and in vivo testing on subcellular endpoints. The testing strategy was conducted in order to demonstrate the suitability of both regulatory testing (OECD tests) as well an in vitro screening strategy on M. eduilis hemocytes to characterize the environmental risk posed by ENMs in the context of safer-by-design and its application to industry. In addition, recommendation and discussion on protocols used to test this CNF are provided.
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Submitted on : Wednesday, August 29, 2018 - 11:17:52 AM
Last modification on : Tuesday, February 8, 2022 - 2:48:02 PM


  • HAL Id : ineris-01863952, version 1



Andrew Barrick, Nicolas Manier, Pascal Pandard, Amelie Chatel, Catherine Mouneyrac. The Application of Ecotoxicological Tools to Safer-by-Design Strategies for Engineered Nanomaterials. 28. SETAC Europe annual meeting, May 2018, Rome, Italy. ⟨ineris-01863952⟩



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